摘要
目的探讨不同病因导致的老年感染性休克患者中血清降钙素原及C-反应蛋白动态表达水平及其临床意义。方法选取华北理工大学附属医院收治的60例不同病因老年感染性休克患者,其中腹部感染并发休克组(腹部组)患者30例,胸部感染并发休克组(胸部组)患者30例,同时选取同期住院的30例非感染性休克老年患者为对照组,分别于治疗前及治疗后第1、3、5天采取静脉血分别检测降钙素原、C-反应蛋白的变化及进行急性生理和慢性健康状况(APACHE)Ⅱ评分,同时判断其预后,采用单因素方差分析对其结果进行分析。结果与对照组比较,腹部组和胸部组患者治疗前血清降钙素原及C-反应蛋白均明显升高(P<0.05),且腹部组较胸部组升高更显著(P<0.05);治疗后2组血清降钙素原、C-反应蛋白于第1、3天逐渐升高,第5天低于第3天水平,且腹部组水平均高于胸部组(P<0.05);腹部组治疗前后APACHEⅡ评分均明显高于胸部组(P<0.05)。结论早期不同病因导致的老年感染性休克患者血清降钙素原及C-反应蛋白的水平升高程度不同,关注其水平变化有助于评估其病情严重程度及预后。
Objective To explore the expression of serum procalcitonin and C-rective protein in the elderly patients suffering from septic shock with different cause. Methods Sixty elderly patients with septic shock in the Affiliated Hospital of North China University of Science and Technology were selected and divided into two groups,abdominal infection group and chest infection group,with 30 patients in each group. Thirty elderly patients without septic shock were selected as control group. The levels of procalcitonin and C-reactive protein in venous blood were detected before and 1 day,3 day,5 days after treatment respectively. APACHE Ⅱ score was assessed and the prognosis was observed. The results was analyzed by one-way ANOVA and T-test. Results Compared with control group,the serum levels of procalcitonin and C-reactive protein were significantly higher in two shock groups before treatment and 1,3,5 days after treatment（ P 0. 05）;there was also significant difference between two shock groups（ P 0. 05）. The serum levels of procalcitonin and C-reactive protein were increased on 1st,3rd day of treatment,and decreased on the fifth day of treatment in two shock groups,and especially higher in abdominal infection group. Before or after treatment,the APACHE Ⅱ score was significantly higher,and prognosis was lower in abdominal group than that in the chest infection group（ P 0. 05）. Conclusions The early changes of serum level of procalcitonin and C-reactive protein are different in elderly septic shock patients induced by different reasons,and these may help to evaluate severity and prognosis of the disease.
出处
《实用老年医学》
CAS
2015年第10期837-839,共3页
Practical Geriatrics
