摘要
目的研究EPO对Ⅲ~Ⅳ期卵巢癌患者化疗所致神经毒性的保护作用。方法将81例Ⅲ~Ⅳ卵巢癌患者分为对照组37例（紫杉醇＋顺铂）与治疗组44例（紫杉醇＋顺铂＋EPO）;记录出现神经毒性的时间和紫杉醇剂量;疗程结束后回访6个月,记录患者神经恢复情况。结果对照组26例出现神经毒性,治疗组20例出现神经毒性,2组差异有统计学意义（P〈0.05）。患者出现神经毒性的时间对照组为（8.6±1.6）周,治疗组为（13.3±2.7）周,2组比较,差异有统计学意义（P〈0.05）;患者出现神经毒性时紫杉醇的剂量对照组为（337.1±51.2）mg,治疗组为（642.9±74.3）mg,2组之间差异有统计学意义,P〈0.05。疗程结束后回访6个月,治疗组较对照组患者神经恢复时间早,P〈0.05。结论EPO对Ⅲ~Ⅳ期卵巢癌患者化疗所致的神经损伤有保护作用,并且可以加快神经损伤的恢复。
Objective To study the protective effect of erythropoietin（EPO） on chemotherapy-induced neurotoxicity injury in stage Ⅲ ~ Ⅳ ovarian cancer.Methods 81 cases of stage Ⅲ ~ Ⅳ ovarian cancer were divided into the control group（37 caces,paclitaxel ＋ cisplatin） and the treatment group（44 cases,paclitaxel ＋ cisplatin ＋ EPO）.Time of emergence of neurotoxicity and the dose of paclitaxel were recorded.Nerve recovery of patients in 6 months after the treatment were recorded.Results 26 cases patients in the control group had neurotoxicity and 20 cases had neurotoxicity in the treatment group,there had significant difference between the 2 groups,P〈0.05.Patients in the control group had neurotoxicity in 8.6 ± 1.6 weeks,the treatment group was 13.3 ± 2.7 weeks,the 2 groups had significant difference,P〈0.05.Patients in the control group appeared neurotoxicity at the dose of paclitaxel was 337.1 ± 51.2 mg,the treatment group was 642.9 ± 74.3 mg,the difference between the 2 groups was significant,P〈0.05.In 6 months after the treatment,the time of neurological recovery in the treatment group was earlier than that of the control group,P〈0.05.Conclusion EPO has protective effect on chemotherapy-induced neurotoxicity injury in stage Ⅲ~ Ⅳ ovarian cancer,and it can accelerate the recovery of nerve injury.
出处
《实用癌症杂志》
2015年第11期1723-1725,共3页
The Practical Journal of Cancer
关键词
促红细胞生成素
卵巢癌
化疗
神经毒性
Erythropoietin（EPO）
Ovarian cancer
Chemotherapy
Neurotoxicity
