摘要
目的:观察硫酸镁联合常频机械通气治疗新生儿持续肺动脉高压(PPHN)的临床效果。方法:选择60例确诊并接受治疗的PPHN患儿,根据就诊时间的不同将其分为观察组与对照组,每组30例。两组均给予常频机械通气,观察组同时给予硫酸镁药物治疗。观察两组治疗前及治疗后6 h、24 h及48 h动脉血气情况,每日监测患者血镁、血钙;治疗前及治疗48 h后采用床旁超声心动图监测肺动脉收缩压(PAP);观察有无不良反应。结果:两组患儿治疗6 h、24 h后,观察组患儿pH值、动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)、经皮血氧饱和度(Tc Sa O2)等指标明显优于对照组,治疗48 h后观察组Pa CO2、Pa O2、pH值和Tc Sa O2指标显著高于对照组,差异有统计学意义(t=11.091,t=6.243,t=18.079,t=15.229;P<0.05)。血镁值浓度水平达到了有效的治疗浓度、血钙值浓度水平维持在正常范围内;观察组患儿PAP下降较对照组显著,差异有统计学意义(t=8.918,P<0.05);治疗中未见明显的不良反应。结论:硫酸镁联合常频机械通气治疗新生儿持续肺动脉高压效果好,技术操作简单,值得推广应用。
Objective： To observe the clinical results of magnesium sulfate and conventional mechanical ventilation in the treatment of persistent pulmonary hypertension of newborn. Methods：Two groups of newborn with PPHN, were treated with conventional mechanical ventilation;The observation group was treated with magnesium sulfate saturation, and then adjusted its amount according to their condition, and then gradually decrease until stopped. Before treatment and after treatment 6 h, 24 h, 48 h, to observe arterial blood gas situation, daily monitoring of blood magnesium and blood calcium. Before treatment and after treatment 48 h, to measure pulmonary artery systolic pressure（PAP）by bedside echocardiography; To observe the adverse reactions. Results： After treatment, the observation group more significantly increased in PH value, PaO2（mmHg）, TcSaO2（%）,and more significantly declined in PaCO2（mmHg） than those in the control group （t=11.091, t=6.243, t=18.079, t=15.229; P〈0.05）. Blood Mg（mmol/L） reached an effective therapeutic concentrations, blood Ca（mmol/L） values were maintained within the normal range;the observation group more significantly declined in PAP（t=8.918, P〈0.05）;there were no serious adverse reaction. Conclusion：There are very good curative effect in the treatment of persistent pulmonary hypertension of newborn, with magnesium sulfate and conventional mechanical ventilation, the technology is simple and worth promotion.
出处
《中国医学装备》
2015年第10期78-81,共4页
China Medical Equipment
关键词
新生儿
肺动脉高压
硫酸镁
常频通气
Newborn
Persistent pulmonary hypertension
Magnesium sulfate
Conventional mechanical ventilation
