摘要
目的探讨缺血性脑卒中病人血清中血清淀粉样蛋白A（SAA）、超敏C-反应蛋白（hs-CRP）与急性卒中治疗低分子肝素试验（TOAST）亚型的关系。方法缺血性脑卒中病人262例（脑梗死组）,其中大动脉粥样硬化型（LAA）62例,心源性栓塞型（CE）29例,小动脉闭塞型（SAO）69例,其他明确病因型（SDE）22例,不明原因型（SUE）80例。应用酶联免疫吸附试验测定其血清SAA浓度,免疫散射比浊法检测其血清hs-CRP浓度。以124例健康体检者作为对照组。结果脑梗死组及LAA组、CE组、SAO组血清SAA水平高于对照组,差异有显著性（F=71.64,q=3.06～20.16,P〈0.05）;SDE组、SUE组与对照组比较差异无显著性（P〉0.05）,LAA组与CE组比较差异无显著性（P〉0.05）。脑梗死组及LAA组、CE组hs-CRP水平明显高于对照组,差异有显著性（t=16.11,F=75.30,q=20.34、18.49,P〈0.01）;LAA组与CE组比较差异无显著性（P〉0.05）。结论缺血性脑卒中病人SAA、hs-CRP水平与TOAST亚型有关,SAA、hs-CRP可作为脑梗死急性期的血清标志物之一。
Objective To explore the relationship between serum amyloid A（SAA）protein,high sensitivity C-reactive protein（hs-CRP）and cerebral stroke TOAST subtype. Methods This study consisted of 262 patients with cerebral ischemic stroke（CIS）,of whom,62 with large artery atherosclerosis（LAA）,29 with cardiogenic embolism（CE）,69 with small artery occlusion（SAO）,22 with other causes,and 80 with unknown origin.Employing immunonephelometric assay,the serum SAA levels were detected,and ELISA was used to detect serum hs-CRP.A control group was made up of 124 healthy individuals. Results The serum SAA levels of patients in CIS group,CE group and SAO group were higher than that in the control group（F=71.64,q=3.06-20.16,P〈0.05）,and the difference of that among other-cause group,unknown-origin group and control group were not significant（P〉0.05）,and that between LAA group and CE group was also not significant（P〉0.05）.The serum levels of hsCRP in LAA and CE groups were higher than that in the control（t=16.11;F=75.30;q=20.34,18.49;P〈0.01）,and no significant difference was noted between LAA and CE groups（P〉0.05）. Conclusion SAA and hs-CRP levels in patients with cerebral ischemic stroke are associated with TOAST subtype,SAA and hs-CRP can be used as one of the serum markers of acute-phase cerebral infarction.
出处
《青岛大学医学院学报》
CAS
2015年第6期701-703,706,共4页
Acta Academiae Medicinae Qingdao Universitatis
