摘要
目的:观察自拟利胆退黄汤治疗妊娠肝内胆汁淤积症的临床疗效。方法:将所有于医院妇产科住院的妊娠肝内胆汁淤积症患者共60例,随机分为治疗组与对照组两组,每组各30例,所有患者均在相同的监护条件下进行监护,基本药物支持治疗给予能量合剂及低分子右旋糖酐静点。对照组给予西药S-腺苷蛋氨酸和地塞米松注射液静点,另外口服熊去氧胆酸和苯巴比妥;治疗组在对照组相同治疗的基础上给予自拟利胆退黄汤口服,每日1剂,分早晚2次口服,每次100 m L,2周为1疗程。所有患者治疗均1疗程后统计疗效及相关观察指标。结果:治疗结束后统计显示,治疗组与对照组临床总有效率分别为96.7%、80.0%,两组相比,治疗组明显优于对照组,有显著性差异(P<0.05)。在改善临床瘙痒症状方面,两组治疗后瘙痒评分分别为(0.67±0.49)、(1.72±.53),两组相比,治疗组明显优于对照组,有显著性差异(P<0.05)。在观察两组治疗结束后肝功能生化指标的比较中,治疗组的ALT、AST、TBA、TBIL、DBIL平均数值均明显小于对照组,与对照组相比,有显著性差异(P<0.05)。比较两组患者的分娩及新生儿情况中显示,治疗组的孕周长于对照组,治疗组的羊水污染发生率及产生出血发生率均少于对照组,两组相比,有统计学差异(P<0.05)。治疗组新生儿的早产率明显少于对照组,新生儿窒息发生率及围产儿死亡率也明显少于对照组,与对照组相比较有显著性差异(P<0.05)。结论:采用口服中药治疗妊娠肝内胆汁淤积症,一方面可以改善孕妇患者的临床症状,减少痛苦,更主要的是可以更大程度的保护胎儿,降低早产儿的发生率、新生儿窒息发生率以及围产儿死亡率,疗效显著,而且对孕妇及胎儿均没有明显不良反应,值得临床推广使用。
Objective： To observe the clinical curative effect of self- made Lidan Tuihuang Decoction of intrahepatic cholestasis of pregnancy. Methods： In our hospital,intrahepatic cholestasis of pregnancy patients with a total of 60 cases,were randomly divided into treatment group and control group,30 cases in each group. All patients were monitored in care under the same conditions,the basic drugs to support the treatment with energy mixture and low molecular dextraninfusion. The control group were given western medicine Sadenosine methionine and dexamethasone injection by intravenous dripping,adding ursodeoxycholic acid and phenobarbital. Treatment group were given self- made Lidan Tuihuang Decoction orally,1 agent a a day,twice a day orally,100 m L each time,2 weeks for 1 course. All treatment,effect and related indexes in all patients were analyzed. Results： After the statistical analysis,the treatment and control groups＇ clinical total effective rates were 96. 7% and 80% and the treatment group was significantly better than the control group（ P 〈0. 05）.In the improvement of clinical symptoms of itching and pruritus scores after treatment in the two groups were（ 0. 67 ±0. 49） and（ 1. 72 ± 0. 53） and the treatment group was significantly better than the control group（ P 〈0. 05）. In the end,the biochemical indices of liver function of two groups were observed after treatment. The treatment group ＇s ALT,AST,TBA,TBIL and DBIL mean values were significantly smaller than those of the control group and there was significant difference（ P 〈0. 05）. Delivery and neonatal cases comparison showed treatment group＇s pregnant weeks were longer and the amniotic fluid pollution rate and bleeding rate were less than those of the control group and there was statistically significant difference（ P 〈0. 05）. The treatment group＇s neonatal premature rate and the perinatal mortality rate of neonatal asphyxia were significantly less than the control group＇s and there was significant difference�
出处
《中华中医药学刊》
CAS
北大核心
2015年第11期2807-2811,共5页
Chinese Archives of Traditional Chinese Medicine
关键词
妊娠肝内胆汁淤积症
利胆退黄汤
中医中药
临床观察
intrahepatic cholestasis of pregnancy
Lidan Tuihuang Decoction
Chinese medicine
clinical observation
