摘要
鼠诺如病毒（routine norovirus，MNV）是唯一可在体外有效扩增的诺如病毒，其病毒株的分离及在鼠巨噬细胞RAW264．7细胞的增殖成功为诺如病毒分子机制的研究奠定了基础，也为人类诺如病毒（HuNoVs）致病机制的研究和疫苗的制备提供了帮助。MNV是小鼠中传播最广泛的感染因子之一，具嗜免疫细胞性，对免疫缺陷小鼠可产生致死性，加强该病毒感染的控制具有重要意义。
Murine norovirus （MNV） is the only norovirus that can be cultivated in vitro. The isolation of the strains and its successful proliferation in the mouse macrophage RAW264.7 cell lay the foundation for molecular mechanism research of norovirus, which also provide help for the pathogenic mechanism research and preparation of vaccine of human norovirus （HuNoVs）. MNV is one of the most widely spread infection factors in mice. The replication of murine norovirus in cell culture reveals a tropism for dendritic cells and macrophages. The virus can make lethal effect on immune-deficient mice. It＇s of great significance to strengthen the control of the virus infection.
出处
《实验动物与比较医学》
CAS
2015年第5期414-420,共7页
Laboratory Animal and Comparative Medicine
基金
国家科技支撑课题（2013BAK11801）
