摘要
目的:制备载透明质酸-甲基胶原-三元共聚物(甲基丙烯酸羟乙酯-甲基丙烯酸甲酯-甲基丙烯酸)/多柔比星复合膜的钽支架,并优化处方。方法:以金属钽支架为载体,透明质酸、甲基胶原、三元共聚物为辅料,利用静电自组装反应制备复合膜。以1、30 d的累积释放度为指标,采用正交设计优化透明质酸、甲基胶原、三元共聚物的质量浓度并验证;考察其体外释药行为。结果:最优处方为透明质酸1 mg/ml、甲基胶原4.5 mg/ml、三元共聚物100 mg/ml;所制钽支架1、30 d的累积释放度分别为7.57%、84.14%,RSD分别为2.3%、2.1%(n=3),20 d后近似呈零级速率释药。结论:成功制得具有缓释功能的载透明质酸-甲基胶原-三元共聚物/多柔比星复合膜的钽支架。
OBJECTIVE： To prepare Hyaluronic acid-methyl collagen-terpolymer（HEMA-MMA-MAA）/Doxorubicin compound membranes-loaded tantalum stent,and to optimize the formulation. METHODS：Electrostatic self-assembly reaction was adopted to prepare compound membranes using metal tantalum stent as carrier,hyaluronic acid,methyl collagen and terpolymer as excipients. With 1 and 30 d accumulative release rate as index,orthogonal test was used to optimize mass concentrations of hyaluronic acid,methyl collagen and terpolymer,and validated. The drug release behavior in vitro were investigated. RESULTS：The optimal formulation was as hyaluronic acid 1 mg/ml,methyl collagen 4.5 mg/ml and terpolymer 100 mg/ml. 1 and 30 d accumulative release rates of prepared tantalum stent were 7.57%（RSD=2.3%,n=3）and 84.14%（RSD=2.1%,n=3）,respectively. 20 d later,dissolution rate approximated to zero level rate of drug release. CONCLUSIONS：Hyaluronic acid-methyl collagen-terpolymer/Doxorubicin compound membranes-loaded tantalum stent with sustained-release property is prepared successfully.
出处
《中国药房》
CAS
北大核心
2015年第31期4424-4426,共3页
China Pharmacy
关键词
多柔比星
金属钽支架
药物缓释系统
静电自组装反应
正交设计
Doxorubicin
Metal tantalum stent
Drug sustained-release system
Electrostatic self-assembly reaction
Orthogonal design
