摘要
恶性肿瘤通过多种机制激活凝血系统,引起高凝状态。高凝状态也能促进肿瘤细胞的增殖和转移。高凝状态易形成静脉血栓栓塞(venous thromboembolism,VTE),VTE是恶性肿瘤常见的并发症,能直接导致患者死亡。妇科恶性肿瘤患者是发生VTE的高危人群。VTE是影响肿瘤患者生存率的重要因素。目前,临床指南推荐传统开腹手术患者术后立即进行最长达28 d的预防性抗凝治疗。对于进行微创手术的妇科肿瘤患者和术后进行化疗的患者,是否常规进行预防性抗凝治疗存在争议,仍需根据患者具体情况进行综合分析。肝素具有一定的抗肿瘤作用,但长期使用预防性抗凝治疗对恶性肿瘤患者预后的影响仍待进一步研究。
Tumor cell can stimulate the procoagulant activity and induce a hypercoagulable state. This tumor hypercoagulability contributes to tumor growth, tumor metastasis and formation of venous thromboembolism. Women with a gynecologic malignancy are considered at high risk of venous thromboembolism（VTE）. Studies demonstrated that VTE negatively impacted patients′ survival. Current guidelines recommend up to 28 days′ VTE thromboprophylaxis in the immediate postoperative period for patients undergoing open surgery. There are no established guidelines for women undergoing minimally invasive gynecologic surgery and chemotherapy. Appropriate prophylactic therapy should be considered according to each patient′ s condition. Heparin is considered to have anti-tumor effect. Whether prolonged thromboprophylaxis can improve patients′ survival needs further investigation.
出处
《国际妇产科学杂志》
CAS
2015年第5期579-582,共4页
Journal of International Obstetrics and Gynecology
关键词
生殖器肿瘤
女(雌)性
抗凝药
肝素
低分子量
静脉血栓形成
静脉血栓栓塞
肺栓塞
Genital neoplasms
female
Anticoagulants
Heparin
low-molecular-weight
Venous thrombosis
Venous thromboembolism
Pulmonary embolism
