摘要
目的比较二甲双胍和胰岛素治疗妊娠期糖尿病(GDM)新生儿影响。方法选取100例饮食无法控制血糖的GDM孕妇,随机分为二甲双胍组和胰岛素组,分别给予二甲双胍和胰岛素治疗。比较两组血糖水平及妊娠并发症,新生儿出生体质量、Apgar评分、脐动脉血pH值、低糖血症和高胆红素血症发生率。结果两组孕妇空腹血糖和餐后血糖水平差异无显著性(P>0.05)。两组新生儿出生体质量、第5分钟Apgar评分<7分和脐动脉血pH值<7.05的例数、低糖血症和高胆红素血症发生率差异均无显著性(P>0.05)。结论二甲双胍和胰岛素治疗GDM效果相当,新生儿结局无显著差异,二甲双胍在一定范围内可用于GDM血糖的控制。
Objective To compare the outcome of neonates of patients with gestational diabetes mellitus（GDM）treated with either metformin or insulin. Methods One hundred women with GDM,their blood sugar was failed to control with diet,were randomized to metformin-treatment group and insulin-treatment group.The blood sugar and pregnancy complications in the women were observed,and neonatal birth weight,Apgar score,pH value of umbilical artery blood,incidence of hypoglycemia and hyperbilirubinemia in newborns were compared between the two groups. Results There was no significant difference between average fasting blood sugar and postprandial blood sugar in both groups（P〉0.05）.No significant differences were found in neonatal birth weight,cases of fifth-min Apgar score of〈7and umbilical artery pH of〈7.05,as well as the incidence of hypoglycemia and hyperbilirubinemia between the two groups（P〉0.05）. Conclusion The effectiveness of metformin and insulin was similar in this study for the treatment of gestational diabetes,and the outcome of newborns was nonsignificant difference.Metformin,in a certain range,may be used to control blood sugar in gestational diabetes.
出处
《齐鲁医学杂志》
2015年第6期715-717,共3页
Medical Journal of Qilu
关键词
糖尿病
妊娠
胰岛素
二甲双胍
婴儿
新生
治疗结果
diabetes,gestational
insulin
metformin
infant,newborn
treatment outcome
