摘要
目的研究醒脑静注射液辅助治疗急性脑梗死的疗效及对患者血清基质金属蛋白酶9（MMP9）、一氧化氮（NO）及一氧化氮合酶（NOS）的影响。方法选择急性脑梗死患者112例作为研究对象，采用数字表法随机分成两组，各56例。对照组接受急性脑梗死的常规治疗。观察组在常规治疗的基础上静脉滴注醒脑静注射液。比较治疗前后两组患者NIHSS评分、运动功能评分和感觉功能评分的变化，观察治疗前后两组患者血清MMP-9、NOS、NO水平的变化。结果观察组总有效率（82．14％）高于对照组（64．29％），差异有统计学意义（x。=4．553，P〈0．05）。治疗后，观察组NIHSS评分均低于对照组，差异均有统计学意义（t=5．082、5．522、6．253，均P〈0．01）。治疗3周，观察组运动功能评分（69．54±17．82）分、感觉功能评分（30．58±7．94）分，均高于对照组运动功能评分（52．93-4-14．66）分、感觉功能评分（23．08±6．31）分，差异均有统计学意义（t：5．387、5．534，均P〈0．01）。治疗后，观察组血清MMP-9、NOS、NO水平均低于对照组，差异均有统计学意义（均P〈0．01）。结论醒脑静注射液辅助治疗急性脑梗死疗效显著，能够促进患者神经功能的恢复，改善运动功能和感觉功能，并通过调节MMP-9、NOS、NO水平起到保护神经血管的作用。
Objective To study the clinical effect of Xingnaojing injection in treating patients with acute cerebral infarction and its influence on serum matrix metalloproteinase 9 （MMP -9）, nitric oxide （NO） and nitric oxide synthase （NOS）. Methods 112 patients with acute cerebral infarction were randomly divided into two groups by random number table method, 56 cases in each group. The control group received routine treatment for acute cerebral infarction. The observation group received routine treatment plus intravenous injection Xingnaojing. The changes of NIHSS score, motor function score and sensory function score in the two groups were compared before and after treatment. The serum levels of MMP - 9, NOS and NO in the two groups were observed before and after treatment. Results The total effective rate of observation group was 82.14% ,which was significantly higher than 64.29% in the control group （X2 = 4. 553,P 〈 0. 05 ）. After treatment, NIHSS scores of the observation group were significantly lower than the control group （ t = 5. 082,5. 522,6. 253, all P 〈 0.01 ）. After treatment for 3 weeks, the motor function score （69. 54± 17.82） points, sensory function score （30.58 ± 7.94） points of the observation group were significantly higher than （52.93 ± 14.66） points and （23.08 ± 6.31 ） points in the control group （ t = 5. 387,5. 534, all P 〈 0. 01 ）. After treatment, the serum MMP -9, NOS, NO levels of the observation group were significantly lower than the control group （ all P 〈 0.01 ）. Conclusion Xingnaojing injection in the treatment of acute cerebral infarction has good curative effect, it can promote the recovery of neurological function, improve motor function and sensory function, and by adjusting the MMP- 9, NOS, NO levels to protect the nerve and blood vessel function.
出处
《中国基层医药》
CAS
2015年第20期3061-3064,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省医药卫生科技计划项目（2014KYB306）
关键词
脑梗死
醒脑静注射液
神经功能
金属蛋白酶9
一氧化氮
一氧化氮合酶
Brain Infarction
Xingnaojing injection
Nerve function
Matrix metalloproteinase 9
Nitric oxide
Nitric oxide synthase
