摘要
目的分析肿瘤标志物糖类抗原19-9(CA19-9)、糖类抗原242(CA242)与胰腺癌患者术后生存质量的关系,初步探讨胰腺癌患者术后复发的病理机制。方法采用AXSYM免疫分析仪检测北京市西城区展览路医院60例胰腺癌患者术后血清中CA19-9和CA242含量,比较术后0.5个月、3个月、6个月复发患者和未复发患者的CA19-9和CA242动态水平,并分析随访患者的临床资料和病理特征。以60例健康体检人员为对照组。结果胰腺癌组患者的CA19-9和CA242水平均较对照组异常升高,其差异有显著统计学意义(P<0.01);术后复发38例,复发组患者的CA19-9和CA242升高率明显高于未复发组,其差异均具有显著统计学意义(P<0.01);术后3个月患者的CA19-9和CA242水平均明显低于术后0.5个月(P<0.05),且此时复发组和未复发组比较差异均无统计学意义(P>0.05);但手术后6个月该两项指标含量较术后3个月明显上升,且复发组明显高于未复发组,差异均有统计学意义(P<0.05)。此外,患者的术后生存时间与肿瘤大小、位置、TNM分期、神经浸润、CA19-9与CA242水平均有关系(P<0.05)。结论肿瘤标志物CA19-9与CA242水平含量异常升高是胰腺癌复发的病理机制之一,水平升高越高,病变越严重,预后越差;水平下降越明显,则患者生存期越长。
Objective To analyze the correlation between tumor marker carbohydrate antigen 19-9 （CA19-9）, carbohydrate antigen 242 （CA242） and postoperative life quality of patients with pancreatic cancer, and to evaluate the pathogenesis of pancreatic cancer recurrence. Methods Sixty patients with pancreatic cancer hospitalized in Beijing Zhanlanlu Hospital were analyzed with AXSYM immune analyzer. The serum CA19-9 and CA242 levels of 0.5 month, 3 months, 6 months after treatment were compared between patients with and without recurrence. Furthermore, the clinical data and pathological features of patients were also analyzed. And 60 healthy volunteers were selected as con-trol group. Results The CA242 and CA19-9 levels of pancreatic cancer patients were higher than those of healthy vol-unteers, and the differences were statistically significant （P〈0.01）. The CA19-9 and CA242 levels in recurrence group （38 cases） were higher than those in non-recurrence group （P〈0.01）. The CA19-9 and CA242 levels were significantly lower at 3 months than 0.5 month after treatment, and there was no statistically significant difference between the recur-rence and non-recurrence group （P〉0.05）. The CA19-9 and CA242 levels were significantly higher at 6 months than 3 months after treatment, and the levels in recurrence group were higher than those in non-recurrence group （P〈0.05）. In ad-dition, the survival time of patients was correlated with preoperative tumor size, location, TNM staging, neural invasion, CA19-9 and CA242 levels （P〈0.05）. Conclusion The increase of CA19-9 or CA242 levels is one of the pathological mechanisms for recurrence of pancreatic cancer. The severity of pancreatic cancer is positively associated with CA19-9 and CA242 levels. With the decrease of CA19-9 and CA242 levels, patient＆#39;s survival time becomes longer.
出处
《海南医学》
CAS
2015年第19期2879-2881,共3页
Hainan Medical Journal
