摘要
目的:评价磷酸钙骨水泥(CPC)、CPC和重组人体骨形态发生蛋白-7(rhBMP-7)复合人工骨(CPC/rhBMP-7)的成骨能力及修复上颌窦上壁骨折的可行性。方法:24只成年新西兰兔制造右侧上颌窦上壁10mm×5mm长的骨缺损模型,随机分为2组,每组12只,分别植入CPC材料和CPC/rhBMP-7材料。在术后6、12周取材进行大体观察、组织学观察、电镜扫描和碱性磷酸酶活性测定,比较骨缺损的修复效果。结果:大体观察、组织学观察和电镜扫描发现单纯的CPC材料组可引导新骨形成,但新骨形成少且慢;CPC/rhBMP-7材料组新生骨形成多、早并且成骨细胞ALP活性增加。CPC/rhBMP-7组碱性磷酸酶含量明显优于CPC材料组(P<0.05)。结论:CPC/rhBMP-7复合材料具有传导成骨和诱导成骨活性,较单独应用CPC材料具有良好的修复上颌窦上壁骨缺损的能力。
Objective：To evaluate the osteogenetic character and repairing maxillary sinus superior wall fractures capability of calcium phosphate cement（CPC）before and after combined with recombinant human bone morphogenetie protein-7（rhBMP-7）. Method： A 10 mm × 5 mm bone defect in the maxillary sinus superior wall was induced by surgery in all 24 New Zealand white rabbits. These 24 rabbits were randomly divided into two groups. The defects were repaired with CPC group（n= 12） and CPC/rhBMP-7 group （n= 12）. The osteogenesis of bone defect was monitored by gross observation, histological examination, observation under scanning electron micro- scope and measurement of ALP activity at 6 and 12 weeks after the implantation. Result： In group CPC, new bone was found to form slowly and little by little. In group CPC/rhBMP-7,however, new bone was observed to form early and massively. The ALP activity in group CPC showed significant statistical difference with that of group CPC/rhBMP-7 （P〈0.05）. Conclusion：The CPC/rhBMP-7 composite has osteoconductibility and osteoinductibility, comparing the use of CPC/rhBMP-7 with CPC for the repair of orbital fracture, the former show obvious advantage repairing ability in maxillary sinus superior wall defect.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2015年第21期1890-1893,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
上颌窦上壁骨折
磷酸钙骨水泥
重组人体骨形态发生蛋白-7
sinus superior wall fractures
calcium phosphate cement
recombinant human bone morphogenetic protein-7
