摘要
目的:评价GA/Hb A1c比值与2型糖尿病颈动脉粥样硬化斑块相关性。方法:选取四川省人民医院内分泌科住院的2型糖尿病患者,收集临床数据进行分析。结果:纳入154例患者,相关分析显示GA/Hb A1c比值与体质指数、血尿酸呈负相关;与年龄、同型半胱氨酸、空腹血糖、餐后血糖、左和右侧颈动脉中层厚度呈正相关。其中颈动脉斑块阳性组与阴性组相比,GA、GA/Hb A1c比值及同型半胱氨酸水平前者显著高于后者。Logistic回归分析显示GA/Hb A1c比值是影响2型糖尿病患者发生颈动脉粥样硬化斑块的独立危险因素(P=0.008)。结论:GA/Hb A1c比值与2型糖尿病患者颈动脉中层厚度呈正相关。这提示GA/Hb A1c比值能作为预测糖尿病患者心血管并发症的潜在临床指标。
Objective To investigate the association between the glycated albumin to glycated hemoglobin（GA / A1c） ratio and carotid plaque. Methods Type 2 diabetic（T2DM） patients in endocrine inpatient department of Sichuan Provincial People′s Hospital were chosen whose clinical data were collected. Results Of the recruited 154 T2 DM patients, GA / HbA1c ratio was negatively correlated with BMI, blood uric acid and was positively correlated with age, HCY, FBG, PBG, left carotid IMT and right carotid IMT. In terms of carotid plaque, GA, GA / HbA1c ratio and HCY were higher in carotid plaque positive patients than those without carotid plaque. The results of logistic regression analysis showed that GA / HbA1c ratio was significantly associated with the presence of carotid plaque（P=0.008）. Conclusions GA / HbA1c ratio was positively correlated with the presence of carotid artery IMT in T2 DM This suggests that GA / HbA1c ratio will serve as a useful clinical marker for predicting diabetic cardiovascular complications.
出处
《实用医学杂志》
CAS
北大核心
2015年第18期2969-2971,共3页
The Journal of Practical Medicine
基金
四川省卫生厅课题项目(编号:110128)
