摘要
目的探讨我国低出生体重儿（10wbirthweightinfant，LBWI）的影响因素，为减少LBWI发生率、改善其围产结局提供参考。方法在中国东北、西北、华北、华中、华东、华南和西南的14个省（自治区、直辖市），抽取39所不同级别的医院，2011年1月1日至12月31日共分娩新生儿112441例。排除基本数据不完整、妊娠28周前流产、因胎儿畸形等原因引产及胎死宫内者，共纳入103678例新生儿，进行回顾性分析。查阅病例资料，填写调查表并录入数据。调查内容包括孕产妇年龄、文化程度、身高、体重、孕产次、不良孕产史、妊娠并发症及合并症。采用独立样本t检验、x^检验和多因素非条件Logistics回归进行统计学分析。结果103678例新生儿中，LBWI发生率为7．21％（7474／103678），早产儿LBWI发生率为61．43％（5260／8562），足月儿LBWI发生率为2．33％（2214／95116）。单因素分析显示，年龄、文化程度、身高、妊娠前体重指数（bodymassindex，BMI）、妊娠期增重、脐带长度、吸烟、产次、不良孕产史、糖尿病、早产、妊娠期高血压疾病、贫血、胎膜早破、羊水量异常等因素均与LBWI相关。将单因素分析中P〈0．3的变量纳入非条件二分类Logistic回归分析，结果显示，早产（OR=46．246，95％CI：41．484～51．555）、妊娠期高血压疾病（OR=5．031，95％CI：4．325～5．853）、既往死胎≥1次（OR=2．446，95％CI：1．479~4．044）、羊水过少（OR=2．068，95％CI：1．659～2．578）、妊娠前体重指数〈18．5（OR=I．637，95％CI：1．415-1．893）、自然流产≥1次（OR=1．362，95％CI：1．043-1．777）、年龄≤20岁（OR=1．332，95％CI：1．046-1．695）、贫血（OR=1．230，95％CI：1．017-1．488）、胎膜早破（OR=1．154，95％CI：1．016～1．311），均为发生LBWI的危险因素；孕妇文化程度越高、妊娠期增重越多、妊娠前BMI越
Objective To investigate the influencing factors of low birth weight infants （LBWI） in China in order to provide evidence for lowering the incidence of LBWI and improving the perinatal outcomes. Methods Clinical data were obtained from 14 different provinces, municipalities or autonomous regions in Northeastern, Northwestern, Northern, Central, Eastern, Southern and Southwestern of China, covering 39 hospitals of different levels. A total of 112 441 newborns were collected from January 1 to December 31 in 2011. After exclusion of those cases with incomplete information, miscarriage before 28 weeks of gestation, induction due to fetal malformation or intrauterine fetal death, 103 678 cases were restrospectively analyzed. Questionnaires were filled out and all data were recorded in computer network databases. Clinical data included maternal age,education background, height, weight, parity, histories of abnormal pregancy and comorbidities and complication. Independent sample t-test, Chi-square test, unvariate and ultivariate unconditional Logistics regression analysis were performed. Results The incidence of LBWI in China's Mainland was 7.21% （7 474/103 678）, 61.43% （5 260/8 562） for preterm babies, and 2.33% （2 214/95 116） for full-term babies. Univariate analysis showed that LBWI were associated with maternal age, education background, height, pregestational body mass index （BMI）, weight gain during pregnancy, cord length, smoking, parity, histories of abnormal pregancy, gestational diabetes mellitus （GDM）, preterm birth, hypertensive disorders in pregnancy, anemia, premature rupture of membranes and abnormal amniotic fluid volume. The following unconditional binary logistic regression analysis for those factors with P 〈 0.3 in unvariate analysis showed that preterm birth （OR=46.246, 95%CI： 41.484- 51.555）, hypertensive disorders during pregnancy （OR=5.031, 95%CI： 4.325-5.853）, histories of intrauterine fetal death ≥ 1 times （OR=2.446, 95%CI： 1.479-4.044）, oligohydramn
出处
《中华围产医学杂志》
CAS
CSCD
2015年第10期755-760,共6页
Chinese Journal of Perinatal Medicine
基金
基金项目：中华人民共和国卫生公益性行业科研专项基金（201002013）
北京市卫生局高层次人才基金（2009-2-11）
