摘要
目的:观察肝炎综合征经验方汤剂直肠滴入联合西药治疗淤胆型婴儿肝炎综合征的临床疗效及对患儿相关指标的影响.方法:经诊治淤胆型婴儿肝炎综合征患者83例,采用随机数字表法分为治疗组42例和对照组41例,对照组患者给予西医常规治疗方案,治疗组在对照组基础上给予中药直肠滴入,每个疗程2 wk,2组均进行3个疗程,观察临床疗效、血生化指标包括血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)、血清总胆汁酸(total bile acids,TBA)、碱性磷酸酶(alkaline phosphatase,ALP)、总胆红素(total bilirubin,TBIL)、直接胆红素(direct bilirubin,DBIL)、谷氨酰转肽酶(gammaglutamyl transpeptidase,GGT)及CMV-Ig M转阴率,肝脏大小等情况.结果:治疗组CMV-Ig M转阴率、总有效率明显高于对照组(P<0.05).两组ALT、TBA、ALP、TBIL、DBIL及GGT均较治疗前明显降低(P<0.05),且治疗组较对照组下降水平更为显著,具有显著性差异(P<0.05).两组肝脏较治疗前明显缩小(P<0.05),治疗后组间比较具有统计学意义(P<0.05).治疗组黄疸消退时间明显短于对照组,具有显著性差异(P<0.05).结论:肝炎综合征经验方汤剂直肠滴入联合西药常规治疗降低婴儿肝炎综合征淤胆型患者的ALT、TBA、ALP、TBIL、DBIL及GGT水平,提高巨细胞病毒感染抗-CMVAg M阴转率.
AIM：To observe the clinical effects of Chinese medicine rectal instillation therapy combined with Western medicine in treating cholestatic infancy hepatitis syndrome and its effect on blood biochemical parameters.METHODS：Eighty-three patients diagnosed with cholestatic infancy hepatitis syndrome were randomized into either a treatment group（n = 42） or a control group（n = 41）.The control group was treated with Western medicine alone,and the treatment group was given traditional Chinese medicine rectal instillation therapy combined with Western medicine.The treatment lasted 6 weeks.After treatment,serum total bilirubin（TBIL）,direct bilirubin（DBIL）,alkaline phosphatase（ALP）,alanine aminotransferase（ALT）,total bile acid（TBA）,gamma-glutamyl transpeptidase（GGT）,CMVIgM negative conversion rate,and liver size were compared between the two groups.RESULTS：The effective rate and CMV-IgM negative conversion rate were significantly higher in the treatment group than in the control group（P〈0.05）.After 6 wk of treatment,the levels of ALT,TBA,ALP,TBIL,DBIL and GGT in both groups improved significantly（P〈0.05）,and were dramatically lower in the treatment group than in the control group（P〈0.05）.The liver size in the treatment group was significantly decreased compared with the control group（P〈0.05）.The time to jaundice disappearance was significantly shorter in the treatment group than in the control group（P〈0.05）.CONCLUSION：Chinese medicine rectal instillation therapy combined with Western medicine can reduce the levels of ALT,TBA,ALP,TBIL,DBIL and GGT,and improve the anti-CMV-IgM negative conversion rate in patients with cholestatic infant hepatitis syndrome.
出处
《世界华人消化杂志》
CAS
2015年第28期4568-4573,共6页
World Chinese Journal of Digestology
基金
河南省教育厅科学技术研究重点基金资助项目
No.13A360559~~
关键词
婴儿肝炎综合征
中药直肠滴入
巨细胞病毒感染
Cholestatic infant hepatitis syndrome
Chinese medicine rectal instillation
Cytomegalovirus infection
