摘要
目的：探讨窄带成像放大内镜（NBI-ME）对早期胃癌的诊断价值。方法：检索Embase、PubMed、Web of Science及Cochrane Library四大数据库，对运用NBI-ME诊断早期胃癌的文献进行meta分析。结果：最终纳入12篇文献，包括2048例患者的2278个病灶，合并灵敏度为0．84（95％CI：0．80-O．87）、特异性为0．96（95％CI：0．95～0．97），综合受试者工作特征的曲线下面积（AUC）为0．9592。NBI-ME联合传统白光内镜亚组的AUC值（0．9706）高于单用NBI-ME亚组（0．8162）。NBI-ME联合传统白光内镜较单用传统白光内镜诊断早期胃癌的增量效应差异具有统计学意义（IY=9．4％，P=0．011），而单用NBI-ME较传统白光内镜的增量效应差异无统计学意义（IY=0．8％，P=0．498）。结论：NBI-ME联合传统白光内镜对诊断早期胃癌具有较高的准确性；而单用NBI-ME较单用传统白光内镜诊断早期胃癌无显著优势。
Objective： To assess the diagnostic value of narrow-band imaging with magnifying endoscopy （ NBI-ME ） for early gastric cancer （ EGC ）. Methods： We searched PubMed, Embase, Web of Science and the Cochrane Library for literature of NBI-ME in diagnosis of EGC, and then performed recta-analysis. Results： A total of 12 articles involving 2 278 samples from 2 048 patients were included. The overall sensitivity of NBI-ME for diagnosis of EGC was 0. 84 [ 95% CI： O. 80 - 0. 87 ], specificity was 0.96 （95% CI： O. 95 -0.97）, and area under the symmetric receiver operator characteristic curve （AUC） was 0. 9592. The AUC value of the NBI-ME plus conventional white light endoscopy （C-WLE） subgroup （0. 9706） was higher than that of NBI-ME alone （0. 8162 ）. The incremental yield of NBI-ME plus C-WLE over C-WLE was significant （/Y = 9.4%, P = 0.011 ）, while NBI-ME alone over C-WLE was not significant （IY = 0.8%, P = 0. 498）. Conclusions： The results show that NBI-ME plus C-WLE is an effective and preferable method for diagnosis of EGC; however, NBI-ME alone is not superior to C-WLE.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2015年第4期435-442,共8页
Journal of Zhejiang University(Medical Sciences)
关键词
胃肿瘤/诊断
胃镜检查
诊断显像
META分析
Stomach neoplasms/diagnosis
Gastroscopy
Diagnostic imaging
Meta-analysis
