摘要
目的探讨肝硬化患者上消化道出血(UGB)的危险因素。方法选择2010年12月至2013年12月安阳市第五人民医院收治的肝硬化患者135例,根据是否合并UGB分为出血组61例和非出血组74例,对2组患者的临床资料及实验室检查指标进行比较,分析肝硬化患者发生UGB的危险因素。结果出血组乙型病毒性肝炎肝硬化、酒精性肝硬化、出血组肝功能Child-Pugh分级C级、中重度腹水、中重度食管胃底静脉曲张、吸烟、饮酒及非甾体抗炎药物应用患者比例显著高于非出血组,差异均有统计学意义(P<0.05)。2组患者血红蛋白、血小板、白蛋白、血肌酐水平及凝血酶原时间比较差异均无统计学意义(P>0.05),但出血组患者血尿素氮水平显著高于非出血组(P<0.05)。结论乙型病毒性肝炎肝硬化、酒精性肝硬化、肝功能不全、严重腹水、严重食管胃底静脉曲张、吸烟、饮酒、非甾体抗炎药物应用及血尿素氮水平升高可能是肝硬化患者发生UGB的危险因素。
Objective To explore the risk factors for upper gastrointestinal bleeding（ UGB） in cirrhosis patients. Methods A total of 135 patients with cirrhosis were selected in the Fifth People＇s Hospital of Anyang City from December 2010 to December 2013. All patients were divided into bleeding group（ n = 61） and non-bleeding group（ n = 74） according to whether with UGB or not. The clinical data and laboratory index were compared between the two groups,then the risk factors for UGB in cirrhosis patients were analyzed. Results Compared with non-bleeding group,the ratios of patients with hepatitis B cirrhosis and alcoholic cirrhosis,liver function Child-Pugh grade C,medium and severe ascites,medium and severe esophageal gastric varices,smoking,alcohol drinking and nonsteroidal antiinflammatory drugs were significantly higher in bleeding group（ P〈0. 05）. There was no significant difference in the level of hemoglobin,platelet,albumin,serum creatinine and prothrombin time between the two groups（ P〉0. 05）. The level of blood urea nitrogen in bleeding group was significantly higher than that in non-bleeding group（ P〈0. 05）. Conclusion Hepatitis B cirrhosis,alcoholic cirrhosis,hypohepatia,severe ascites,severe esophageal gastric varices,smoking,alcohol drinking,using nonsteroidal antiinflammatory drugs and blood urea nitrogen increasing may be the risk factors for UGB in cirrhosis patients.
出处
《新乡医学院学报》
CAS
2015年第9期856-857,860,共3页
Journal of Xinxiang Medical University
关键词
肝硬化
上消化道出血
危险因素
cirrhosis
upper gastrointestinal bleeding
risk factor
