摘要
目的:探讨血清超氧化物歧化酶(SOD)活性和胱抑素C(Cys C)浓度在类风湿关节炎(RA)患者并发早期肾损伤中的临床意义。方法:108例RA患者根据尿白蛋白排泄率(UAER)分为肾损害组、无肾损害组,同期50例健康体检者作为对照组,在全自动生化分析仪上测定血清SOD活性、Cys C、尿素氮(BUN)和肌酐(Cr)浓度,并比较3组患者上述各项指标的差异。结果:1RA肾损害组SOD活性为(85.74±20.19)U/m L,与RA无肾损害组[(96.51±21.98)U/m L]、健康对照组[(114.58±18.90)U/m L]相比均明显降低(P值分别<0.05,<0.01);RA无肾损害组SOD活性为(96.51±21.98)U/m L,与健康对照组[(114.58±18.90)U/m L]相比明显降低(P<0.01);SOD阳性率在RA肾损害组(98%)和无肾损害组(95%)均高于健康对照组(75%,χ2分别为13.54,10.30,P值均<0.01);RA肾损害组Cys C浓度为(1.20±0.26)mg/L,与健康对照组[(1.07±0.22)mg/L]相比明显升高(P<0.01),RA肾损害组Cys C浓度[(1.20±0.26)mg/L]与RA无肾损害组[(1.16±0.27)mg/L]相比,差异无统计学意义;RA无肾损害组Cys C浓度[(1.16±0.27)mg/L]与健康对照组相比[(1.07±0.22)mg/L],差异无统计学意义;2RA肾损害组患者UAER水平与血清Cys C浓度变化呈正相关(r=0.396,P<0.01),与SOD血清活性呈负相关(r=-0.667,P<0.01)。结论:检测血清SOD活性及Cys C浓度有助于发现RA早期肾功能损伤。
Objectlve：To investigate the significance of serum superoxide dismutase （SOD） activity and cystatin C （Cys C ）concentration in identifying early kidney injury in rheumatoid arthritis（RA）. Methods ： 108 RA patients were allocated to group with renal injury or without renal involvement based on urinary albumin excretion rate（UAER） ,and another 50 healthy individuals were recruited as normal controls. SOD activity and levels of Sys C,blood urea nitrogen （ BUN ） and creatinine（Cr） were determined with automatic biochemical analyzer and compared regarding the difference of the indicators among the groups. Results：SOD activity was significantly lower in the group with renal injury（ 85.74 ± 20.19）U/mL than that of patients without renal involve- merit （96.51 ± 21.98 ） U/mL and the healthy controls （ 114.58 ±18.90） U/mL（ P 〈 0.05 ;P 〈 〈 0.01 ）, and patients without renal involvement had low- er SOD activity （96.51 ±21.98 ） U/mL than the healthy controls （ 114.58 ± 18.90） U/mL） （ P 〈 0. 01 ）. Higher positivity of serum SOD （98%） was seen in the group of RA with renal injury as compared with RA patients without renal involvement（95% ） and the healthy controls（72% ） （ x^2 = 13.54 ,x^2 = 10.30 ; Both P 〈 0.01 ）. RA patients with renal injury had elevated Cys C concentration [ （ 1.20± 0.26 ） mg/L than healthy controls （ 1.07 ± 0.22 ） rag/ L], whereas showed no significant differences with patients without renal involvement [ （ 1.20 ±0.26） mg/L vs. （ 1.16 ± 0.27 ） mg/L ], and the difference was not significant between RA patients without renal involvement and healthy controls（ 1.16 ± 0.27 ） mg/L vs. （ 1.07± 0.22 ） mg/L. The UAER level was positively correlated with Cys C level in patients with renal injury（ r = 0. 396, P 〈 0.01 ）, yet negatively with SOD activity（ r = - 0. 667, P 〈 0.01 ）. Conclusion ： Determination of serum SOD activity and Cys C concentration may help identify the early renal
出处
《皖南医学院学报》
CAS
2015年第5期427-429,共3页
Journal of Wannan Medical College
