摘要
血管紧张素转换酶抑制剂(Angiotensin converting enzyme inhibitors,ACEI)通过肾素-血管紧张素系统(RAS)和激肽释放酶-肽酶系统(KKS),抑制血管紧张素II的生成,减少缓激肽的降解,从而达到降血压的目的;植物来源的天然化合物具有来源广泛、结构多样、特异性高、毒性低等特点,因而从植物中筛选安全有效的ACEI成为研究热点。在此综述了血管紧张素转换酶(ACE)的活性测定方法以及植物来源的不同结构类型的ACEI研究进展。
Angiotensin converting enzyme inhibitors （ACEI） inhibit the formation of angiotensin II, reduce the degradation of bradykinin by the renin-angiotensin system （RAS） and kallikrein-peptide enzyme system （ KKS）, so as to achieve the purpose of lowering blood pressure. Plant- derived natural products have a lot of advantages, such as a wide range of sources, structural diversity, highly specificity and low toxicity. Therefore, screening of safe and effective ACEI derived from plant become a hot topic. This paper reviewed both the methods of determination of Angiotensin converting enzyme inhibiting activity and the Angiotensin converting enzyme inhibitors derived from plants based on the chemical structure.
出处
《安徽农业科学》
CAS
2015年第29期23-26,共4页
Journal of Anhui Agricultural Sciences
基金
北京高等学校青年英才计划项目(YETP1747)
关键词
ACE活性测定
植物源化合物
Determination of Angiotensin converting enzyme inhibitor activity
Angiotensin converting enzyme inhibitors
Plant-derived natu-ral products
