摘要
在水相中,以水杨醛和卡巴肼为原料,室温下高产率合成了1-(2-羟基苯亚甲基)卡巴肼(3),随后以乙醇/冰醋酸为混合溶剂、微波功率为350 W、温度为120℃和其他芳香醛/酮反应16~30 min得到1,5-二取代卡巴肼衍生物4a^4p,并用IR、1H NMR、13C NMR和元素分析对其结构进行了表征.与传统的方法相比,该法具有简单、快速、高效和对环境友好等优点,为不对称双席夫碱的合成提供一定的参考.X射线衍射分析表明化合物4i属于单斜晶系,P21/c空间群.
A series of asymmetrical 1,5-disubstituted carbonohydrazides 4a-4p were synthesized by the condensation of various substituted aromatic aldehydes and 1-（2-hydroxyphenylidene）carbonohydrazide（3） under microwave irradiation at 120 ℃ and 350 W in ethanol-sulfuric acid mixture for 16-30 min. The starting materials 3 was synthesized using salicylaldehyde and carbohydrazide under water at room temperature. The new synthesized compounds were characterized by IR, ^1H NMR, ^13C NMR spectra and elemental analysis. Compared with the conventional heating method, this method is simple, fast, efficient and eco-friendly. This reaction is expected to be a powerful tool for the synthesis of asymmetrical Schiff bases compounds. The X-ray diffraction analysis indicates that the compound 4i belongs to monoclinic, space group P21/c.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2015年第9期1975-1980,共6页
Chinese Journal of Organic Chemistry
基金
甘肃省自然科学基金(No.1208RJZM289)
庆阳市科技局工业支撑重点(No.KZ2014-27)资助项目~~
关键词
不对称1
5-二取代卡巴肼
合成
表征
微波辐射
晶体结构
asymmetrical 1
5-disubstituted carbonohydrazide
synthesis
characterization
microwave irradiation
crystal structure
