摘要
目的探讨血清胱抑素C(Cys C)在慢性心力衰竭(CHF)患者中的表达水平及其与心功能、心室重构的关系。方法入选CHF患者75例为CHF组,按照NYHA分级分为NYHAⅡ、Ⅲ、Ⅳ级组;按照血清Cys C水平分组:Cys C>0.95 mg/L为Cys C水平升高组,Cys C≤0.95 mg/L者为Cys C正常组;按照左室射血分数(LVEF)分组:LVEF≥0.50为LVEF保留组,LVEF<0.50为非LVEF保留组;入选35例老年健康体检者为对照组。分别测定Cys C、N末端B型利钠肽原(NT-pro BNP)、血肌酐(Scr)、尿素(UREA)、心脏彩超等指标,并进行相关性分析。结果 CHF组患者血清Cys C水平明显高于对照组,且随着NYHA心功能分级增高,其水平也随之升高;与Cys C正常组比,Cys C水平升高组NT-pro BNP较高,而LVEF较低(均P<0.05);与非LVEF保留组比,LVEF保留组NT-pro BNP、左室舒张末容积(LVEDD)、左室质量指数(LVMI)、Cys C较低(均P<0.05);Cys C与年龄、NT-pro BNP、LVEF、LVEDD、Scr、UREA相关(r分别为0.411、0.658、-0.465、0.310、0.552、0.486,P<0.01)。结论血清Cys C可用于评估早期心衰患者的心功能状况,与心室重构相关。
Objective To explore serum Cystain C （Cys C） level in chronic heart failure （CHF） patients and its relation-ship with cardiac function and ventricular remodeling. Methods Patients with heart failure （n=75） and healthy adult （n=35） were enrolled in this study. According to the NYHA classification,CHF patients is divided into NYHA Ⅱ, NYHAⅢand NYHAⅣ;CHF patients can also be divided into 2 groups base on their level of serum Cys C：Cys C〉0.95 mg/L is defined as elevated serum Cys C group, serum Cys C≤0.95 mg/L is defined as normal serum Cys C group;According to left ventricu-lar ejection fraction （LVEF）, CHF patients can also be divided into 2 groups：LVEF≥0.50 is defined as ejection fraction re-served group, LVEF〈0.50 is defined as the ejection fraction reduced group. Cys C, N terminal B-type natriuretic peptide （NT-proBNP）, serum creatinine（Scr）,UREA and Echocardiography were analyzed in all groups and their correlation was studied. Results Serum Cys C level in CHF patients was obviously higher than that in healthy controls, and it increased with NYHA heart function classification;compared with normal Cys C group,Cys C elevated group presented higher NT-proBNP level but lower eGFR and LVEF （P〈0.05）;compared with ejection fraction reduced group, ejection fraction reserved group demonstrated lower NT-proBNP, LVEDD, LVMI and Cys C levels （all P〈0.05）;Correlation analysis revealed that Cys C is correlated with age, NT-proBNP, LVEF, LVEDD, Scr and UREA （r=0.411, 0.658, 0.465, 0.310, 0.552, 0.486, P〈0.01）. Conclusion Serum Cys C can be used to evaluate cardiac function of heart failure, and is associated with ventricular remodeling.
出处
《天津医药》
CAS
2015年第10期1162-1165,共4页
Tianjin Medical Journal
基金
国家自然科学基金青年科学基金项目(81200158)
