摘要
目的研究松脂皱皮孔菌发酵液的化学成分。方法发酵液采用硅胶柱、中压RP-18柱、Sephadex LH-20凝胶柱等色谱方法进行分离纯化,然后根据理化性质和波谱数据对所得化合物进行结构鉴定。结果从中分离出10个化合物,分别鉴定为rosenonolactone(1)、2-nonyne-1,4-diol(2)、1-hydroxy-2-nonyn-4-one(3)、过氧麦角甾醇(4)、麦角甾-4,6,8(14),22-四烯-3-酮(5)、麦角甾-5,7,22-三烯-3β-醇(6)、麦角甾-7,22-二烯-3β,5α,6β-三醇(7)、anti-1-(4-methoxyphenyl)proane-1,2-diol(8)、syn-1-(4-methoxyphenyl)proane-1,2-diol(9)、1-phenylpropane-1,2-diol(10)。结论所有化合物均为首次从松脂皱皮孔菌发酵液中分离得到。
AIM To study chemical constituents from the fermentation broth of Ischnoderma resinosum.METHODS Fermentation broth was isolated and purified by silica,medium pressure Rp-18 and Sephadex LH-20 gel column. The chemical structures of isolated compounds were then elucidated by physicochemical characters and spectral data. RESULTS Ten compounds were isolated from this fungus and identified as rosenonolactone（ 1）,2-nonyne-1,4-diol（ 2）,1-hydroxy-2-nonyn-4-one（ 3）,（ 22 E,24R）-5α,8α-epidiory-ergosta-6,22-dien-3β-ol（ 4）,（ 22 E,24R）-ergosta-4,6,8（ 14）,22-tetraen-3-one（ 5）,（ 22 E,24R）-ergosta-5,7,22-trien-3β-ol（ 6）,（ 22 E,24R）-ergosta-7,22-dien-3β,5α,6β-triol（ 7）,anti-1-（ 4-methoxyphenyl） proane-1,2-diol（ 8）,syn-1-（ 4-methoxyphenyl） proane-1,2-diol（ 9）,1-phenylpropane-1,2-diol（ 10）. CONCLUSION All compounds are isolated from the fermentation broth of Ischnoderma resinosum for the first time.
出处
《中成药》
CAS
CSCD
北大核心
2015年第10期2208-2211,共4页
Chinese Traditional Patent Medicine
关键词
松脂皱皮孔菌
发酵液
化学成分
分离鉴定
Ischnoderma resinosum
fermentation broth
chemical constituents
isolation and identification
