摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并2型糖尿病(T2DM)患者外周血清中白介素6(IL-6)水平变化特点和意义。方法:对35例OSAHS患者(OSAHS组)、48例OSAHS合并T2DM的患者(OSAHS+T2DM组)和健康对照者20例(对照组)采用双抗体夹心酶联免疫吸附法检测并比较3组的血清IL-6水平。结果:OSAHS+T2DM组血清IL-6水平高于OSAHS组和健康对照组(P<0.05);OSAHS组血清IL-6水平高于健康对照组。结论:IL-6等炎性因子可能参与了OSAHS患者引起糖代谢异常的病理生理过程;且与OSAHS相关2型糖尿病的发生发展可能存在密切关系。
Objective：To explore the changes of serum interleukin-6 （IL-6） level in patients with obstructive sleep apnea hypopnea syndrome （OSAHS） and OSAHS associated type 2 diabetes mellitus （T2DM） and their significance. Method： All observed subjects were divided into 3 groups： 20 cases of normal subjects, 35 cases of simple OSAHS patients, 48 cases of OSAHS associated T2DM patients, IL-6 concentrations of serum were measured by the enzyme-linked immunosorbent. Result：IL-6 level was higher in the group of OSAHS with T2DM than the group of OSAHS and the healthy control group （P〈0.05） ; IL-6 level was higher in the simple OSAHS group than the healthy controls. Conclusion：IL-6 and other inflammatory factors may involved pathological physiological process in OSAHS patients sugar metabolic ahnormalities; and is associated with the development of OSAHS associated with type 2 diabetes.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2015年第19期1726-1728,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
天水市科技局项目【天财建(2014)389号】
