摘要
目的探讨透明质酸(HA)治疗对腹腔镜下盆腔手术术后粘连(PA)的预防作用以及其对血液流变学指标(HI)的影响。方法选择2012年5月至2014年5月在接受手术治疗的妇产科盆腔疾病患者200例,随机将患者分为观察组和对照组两组,各100例。其中,对照组患者进行常规的腹腔镜下盆腔手术治疗;而观察组进行手术治疗的同时应用HA以预防PA的发生。对比两组手术前后粘连率、重度粘连率、血清炎症因子[包括白介素10(IL-10)、IL-6、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)]浓度以及HI参数。结果观察组在手术后,其粘连率、重度粘以及HI参数显著降低,血液炎症因子浓度显著升高,差异具有统计学意义(P<0.05);观察组术后粘连率、重度粘连率、术后血清炎症因子浓度以及HI参数均显著低于对照组,差异具有统计学意义(P<0.05)。结论 HA治疗能显著改善各种血液环境,对患者腹腔镜下盆腔手术后发生PA具有明显的预防作用,进而对盆腔手术患者的治疗具有重要价值。
Objective To observe the influence on hemodynamic indexes and the clinical effect of hyaluronan in the prevention of adhe-sions after abdominal - pelvic surgery. Methods 200 patients with pelvic disease accepting the surgical treatment between May 2012 to May 2014 were selected. All patients were randomly divided into observation group and control group,each of 100 cases. Control group was given abdominal- pelvic surgery treatment;while the observation group was given preventive treatment with HA based on the control group. The rates of adhe-sions,severe adhesions,serum inflammatory factor（IL - 10,IL - 6,CRP,TNF - α）and hemorheology indexes between the two groups before and after the treatment were recorded and analyzed. Results The rates of adhesions,severe adhesions,serum inflammatory factor and hemorheol-ogy indexes after the treatment were significantly lower than before the treatment,the difference was statistically significant（ P ﹤ 0. 05）. The rates of adhesions,severe adhesions,serum inflammatory factor and hemorheology indexes in the observation group were significantly lower than in the control group,the difference was statistically significant（ P ﹤ 0. 05）. Conclusion HA treatment can significantly improve blood environment. PA has an obvious prevention function in patients after laparoscopic pelvic surgery,and it also has an important value for the treatment of patients with pelvic surgery.
出处
《临床和实验医学杂志》
2015年第19期1600-1603,共4页
Journal of Clinical and Experimental Medicine
