摘要
目的:探讨SOX与FOLFOX6化疗方案治疗老年晚期胃癌患者的临床疗效。方法:选择2009年10月~2014年10月本院收治的老年晚期胃癌患者共80例,按照随机数字表法随机分为实验组和对照组,实验组采用SOX化疗方案,对照组采用FOLFOX6化疗方案,对两组患者近期有效率、疾病控制率和不良反应发生状况进行评价。结果:两组近期有效率及治疗控制率比较,差异无统计学意义(P>0.05)。两组患者不良反应主要表现为口腔炎症、胃肠道反应和骨髓抑制,主要以I^II级常见。两组患者口腔炎、腹泻、白细胞减少、贫血和血小板减少的差异均无统计学意义(P>0.05),实验组患者恶心呕吐发生率为(19.05%)明显低于对照组发生率(42.11%),差异有统计学意义(P<0.05)。结论:SOX和FOLFOX6化疗方案治疗老年晚期胃癌患者疗效、不良反应发生状况基本相似,但SOX化疗方案胃肠道副反应更少,且应用方便,值得在临床上推广应用。
Objective： To explore the clinical effect of SOX and FOLFOX6 in the treatment of elderly patients with advanced gastric cancer. Methods： A total of 80 elderly patients with advanced gastric cancer, who were treated in Shangnan Hospital from October2009 to October 2014, were randomly divided into experiment group（n=42） and control group（n=38）. The experiment group was treated with SOX chemotherapy, while the control group, with FOLFOX6 chemotherapy. The recently effective rate, control rate and incidence of adverse reactions were evaluated. Results： There were no significant differences in the recently effective rate and control rate between the two groups（P〉0.05）. The main adverse reactions in the two groups were oral inflammatory, gastrointestinal side effects and bone marrow suppression, mainly in the grade I^II. There were no significant differences in the stomatitis, diarrhea, leukopenia, anemia and thrombocytopenia between the two groups（P〉0.05）. The incidence of nausea and vomiting（19.05%） in the experiment group was significantly lower than that（42.11%） in the control group, the difference was statistically significant（P〈0.05）. Conclusions： SOX chemotherapy, in the clinical effect and adverse reactions, is similar to FOLFOX6 chemotherapy in the treatment of elderly patients with advanced gastric cancer, but SOX chemotherapy has few gastrointestinal side effects and is easy to use, which is worthy of clinical application.
出处
《现代生物医学进展》
CAS
2015年第27期5356-5358,共3页
Progress in Modern Biomedicine
