摘要
目的：探讨老年艾滋病抗病毒治疗的临床安全性。方法选取患有艾滋病的老年患者40例作为研究对象，给予抗病毒治疗30个月，观察病毒的完全抑制率、不确定或者失败率、治疗前后各时间点患者CD4细胞计数的变化趋势。结果治疗后各时间点的CD4细胞计数高于治疗前各时间点CD4细胞计数，治疗12个月时患者的CD4细胞增幅超过每微升100个，治疗有效，免疫功能得到重建；治疗6个月时抗病毒治疗的病毒完全抑制率为80．00％，6个月以后病毒的完全抑制率维持在77．50％～85．00％，差异有统计学意义（P＜0．05）。结论老年艾滋病抗病毒治疗后CD4细胞计数有明显改善，病毒的完全抑制率高，不确定和不完全抑制率低，并且病毒抑制持续时间长，免疫功能得到重建，安全性高，值得在临床上推广使用。
Objective To analyze the clinical effect and safety in the anti‐viral treatment of elderly patients with AIDS .Methods 40 elderly patients with AIDS in our hospital from January 2008‐ January 2014 were selected as the study subjects and given the 30‐month anti‐viral treatment of AIDS .The virus completely inhibition rate ,uncer‐tain or failure rate and change trends of CD4 cell count at various time points patients before and after treatment were observed .Results The CD4 cell count at various time points after treatment was absolutely higher than that at the various time points before treatment ,the increase in CD4 cells at 12 months of treatment exceeded 100 per microliter , showing that the treatment was effective and the immune function obtained the reconstruction ;the viral complete in‐hibition rate at 6 months of therapy was 80 .00% ,and which maintained at 77 .50% - 85 .00% after 6 months ,the difference was statistically significant（P〈 0 .05） .Conclusion The CD4 cell count is significantly improved after the anti‐viral therapy in the elderly patients with AIDS ,has higher viral complete inhibition rate ,lower uncertain and in‐complete inhibition rate ,the immune function obtains the reconstruction ,the safety is high ,which is worthy of being widely promoted and used in clinic .
出处
《检验医学与临床》
CAS
2015年第19期2902-2903,2906,共3页
Laboratory Medicine and Clinic
