摘要
以PGI—ELISA定量检测452对麻风患者的家内接触者(HC)和其住宅周围的随机人群(RP)中的亚临床感染、并对结果进行了配对分析。结果表明“①HC中的阳性率(26.11％)高于RP的(20.79％)两者有显著差异(P<0.01)、提示与病人长期密切接触可增加感染的机率;②HC(男22.10％、女28.78％)和RP(男16.57％,女23.62％)均显示其阳性率女高于男(P<0.05),值得进一初探讨③阳性年龄专率显示15～25岁的HC与RP均高(27.13％与27.56％),HC中6～14岁HC的,(24.47％)高率RP者(17.35％),P<0.05故应注意在青少年接触者中均以接触病人;④MB的HC(LL34.84％、BL28.40％)阳性率高于PB的,P<0.01、而在RP则无此现象;⑤在HC与RP中均以接触治愈的人中,其阳性率以HC(24.44％)高于RP(17.7％),P>0.01。这提示带菌量与细菌活力,接触的频率及密切程度都可能是形成“亚感”的重要因素。
Determination of Subclinical infection with M. leprae in 452 household contacts of leprosy patients (HC) and random residents(RR) around the patients home paired with the contacts, using PGI-ELISA, showed the results as follows: 1, the positivity in the HC is 26. 11%, higher than 20.79% in the RR(P<0.01), suggesting that longterm and intimate contact with leprosy patients could enhance the probability of infection; 2, the positive rate is 22.10% in male and 28.78% in female among the HC while the rate is 16.57% in male and 23.62% in female among the RR, manifesting higher, level in female than in male among both the HC and RR; 3, the positive rates in the group aged 15—25 among both the HC and RR are 29.13% and 27.56% respectively, but in the group aged10—14 24.19% in the HC is higher than 17.35% in the RR(P<0.05); 4, the positive rates in the HC with LL and BL patients are 34.84% and 28.40% respectively, being higher than in the HC with PB(P<0.01), but there is no such phenomenon in the RR; 5, Either in the HC or in the RR the positive rates all are higher in those contacting with and living around active cases of leprosy, being 27.75% and 23.79% respectively, but among the contacts with cured cases, the rate in the HC is 24.44%, being higher than 17.77% in the RR. The authors believe that the load and vitality of M. leprae in the contacted patients plus frequence and intimate degree of the contact are main factors which could cause the subetinical infection with M. leprae.
