摘要
目的分析血清炎症因子与慢阻肺急性加重期肺功能的相关性。方法分析2014年1月至2015年1月在我院接受诊疗的慢阻肺患者的临床资料。依据患者疾病活动状态分为两组,观察组(急性加重期)及对照组(稳定期)。结果本研究共纳入慢阻肺患者86例,其中观察组46例,对照组40例。观察组患者血清TNF-α水平显著高于对照组(t=2.924,P=0.004);观察组患者血清IL-10水平显著低于对照组,差异具有统计学意义(t=3.093,P=0.003)。观察组患者FEV_1值、FEV_1/FVC值及FEV_1%值均显著低于对照组(P<0.001)。Pearson相关性分析显示,观察组血清TNF-α水平与FEV_1呈现显著负相关(r=-0.440,P=0.002);观察组血清IL-10水平与FEV_1呈现显著正相关,具有统计学意义(r=0.629,P<0.001)。结论血清炎症因子与慢阻肺患者肺功能密切相关,可用以辅助临床诊疗。
Objective To analyze the correlation between pulmonary function and serum inflammatory fac-tors in patients with COPD. Methods The clinical data of COPD patients from 2014 to 2015 were analyzed, and they were divided into two groups based on disease severity. Results A total of 86 patients were analyzed, 46 cases in the group A and 40 cases in the group B. The level of TNF-αwas obviously higher in the group A than in the group B （t=2. 924, P =0. 004）. The level of IL-10 was lower in the group A than in the group B （t =3. 093, P =0. 003）. The value of FEV1, FEV1/FVC and FEV1% was obviously lower in the group A than in the group B （P〈0. 001）. Correlation analysis showed that the level of FEV1 was positively correlated with IL-10 （r=0. 629, P〈0. 001） and negatively correlated with TNF-α（r= -0. 440, P=0. 002）. Conclusion The increased level of TNF-α and decreased level of IL-10 may be the main markers for acute exacerbation of COPD, which could guide the clini-cal treatment of COPD and have certain significance in judging the severity of COPD.
出处
《临床肺科杂志》
2015年第11期2067-2069,共3页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
肺功能
炎症因子
相关性分析
chronic obstructive pulmonary disease
pulmonary function
inflammatory factor
correlation a-nalysis
