摘要
[目的]观察生血方联合常规治疗ⅡB-ⅢB期宫颈癌同步放化疗骨髓抑制疗效。[方法]使用随机平行对照方法,将49例住院患者按抽签法简单随机分为两组。对照组23例同步放化疗第1d起口服利可君20mg/次,3次/d;复发阿胶浆20m L/次,3次/d;外照射瓦里安-23EX加速器,6MV-X线根治性调强放疗,DT 50Gy/25fx,5fx/w;腔内放疗Ir192,DT24Gy/4fx,1fx/w;化疗单药顺铂50mg/w×5w方案;常规治疗:同步放化疗期间白细胞(WBC)<3.0×109/L,重组人粒细胞集落刺激因子(300ug/支)300ug皮下注射,1次/d,至WBC>4.0×109/L。血小板(BPC)<50×109/L,白介素-11(1.5mg/支)1.5mg皮下注射,1次/d,至BPC>80×109/L;若血红蛋白(HGB)<60g/L,输红细胞悬液至HGB>70g/L。治疗组26例生血方(生黄芪30g,白术炒12g,茯苓15g,山药30g,菟丝子15g,枸杞子、女贞子各15g、鸡血藤30g),1剂/d,2次/d;同步放化疗方案及常规治疗同对照组。连续治疗40d为1疗程。观测血常规(WBC、HGB、BPC)、不良反应。治疗1疗程,判定疗效。[结果]两组血常规指标均下降(P<0.05),治疗组在白细胞及血小板方面优于对照组(P<0.05)。[结论]生血方联合常规治疗ⅡB-ⅢB期宫颈癌同步放化疗骨髓抑制,疗效满意,无严重不良反应,值得推广。
[Objective]To observe Shengxue party combined with routine therapy II B-II1B cervical cancer chemoradiotherapy,bone marrow suppression effect.[Method]Randomized,parallel controlled method,49 cases of hospitalized patients were randomly divided into two groups by drawing lots method is simple.The control group of 23 patients chemoradiotherapy Article ld began oral profitable Jun 20 mg/time, 3 times/d;relapse A mortar 20mL/time,3 times/d.Varian-23EX external irradiation using aceelerators,6MV-X line radical IMRT,DT 50 Gy/25fx,5 fx/w;hrachytherapy using Ir192,DT 24 Gy/4fx,1 fx/w;chemotherapy as monotherapy cisplatin 50 mg/ w x 5w program.Conventional treatment： chemotherapy concurrent radiotherapy leukocyte （WBC）〈3.0 x 109/ L,recombinant human granulocyte colony stimulating factor （300 ug/branch） 300ug subcutaneously,1 times/ d,to WBC〉4.0 x 109/L.Platelets （BPC）〈50 x 109/L,interleukin-11（1.5mg / branch）l.Smg subcutaneous injection,1 times/d,to BPC〉80 × 109/L.If the hemoglobin （HGB）〈60 g/L,lose red blood cells to HGB〉70 g/ L.The treatment group 26 cases Shengxue party （Health Astragalus 30g,Atractylodes fry 12g,Poria 15g,Chinese yam 30g,Dodder 15g,medlar,Ligustrum lucidum the 15g,Millettia 30g）,1 dose/d,2 times/d;synchronization put chemotherapy and conventional treatment with the control group.40d for a course of continuous treatment. Observing blood（WBC,HGB,BPC）,adverse reactions.One course of treatment,to determine effieacy.[Results] index decreased blood groups （P〈0.05）,the treatment group than the control group（P〈0.05）in terms of white blood cells and platelets.[Conclusion]Blood Fang combined with routine therapy Ⅱ B- ⅢB cervical cancer chemoradiotherapy,bone marrow suppression,resuhs were satisfactory,no serious adverse reactions,it is worth promoting.
出处
《实用中医内科杂志》
2015年第9期101-103,共3页
Journal of Practical Traditional Chinese Internal Medicine
