摘要
目的评价OPG基因A163G和T950C的多态性与骨质疏松发病风险的相关性。方法在万方数据库、中国知网、中国生物医学文献数据库、Pub Med数据库中全面检索关于OPG基因启动子A163G和T950C多态性与骨质疏松相关的文献,对纳入的文献进行质量评价,并采用Rev Man5.3软件进行meta分析。结果共有13篇文献被纳入本次的meta分析,关于A163G的文献有7篇,累计骨质疏松病例组805人,健康对照组948人;关于T950C的文献有8篇,累计骨质疏松病例组1286人,健康对照组1252人。关于A163G的meta分析显示等位基因G可能会增加骨质疏松的风险[OR=1.37,95%CI:1.12-1.68,P=0.003],在高加索人、男性和女性及绝经后妇女的亚组分析中显示同样的结果。关于T950C的meta分析显示等位基因T、C在增加骨质疏松的风险上无统计学意义[OR=1.03,95%CI:0.82-1.28,P=0.004],在种族和性别的亚组分析中同样无统计学意义。结论 OPG基因T950C的多态性并没有证实与骨质疏松的风险有关,但A163G的多态性可能会增加骨质疏松的风险。
Objective To evaluate the relationship between OPG gene A163G and T950C polymorphisms and the risk of osteoporosis. Methods The relationship between OPG gene promoter T950C and A163G polymorphisms and osteoporosis in the literatures of Wanfang, CNKI, CBM, and PubMed was comprehensively searched. Data extracted from the literatures were evaluated The statistical analysis was conducted using a RevMan5.3 software. Results Thirteen published articles were selected for meta-analysis. Among them, there were 7 studies about A163G, including 805 subjects in the osteoporosis group and 948 subjects in the healthy control group. There were 8 studies about T950C, including 1286 subjects in the osteoporosis group and 1252 subjects in the healthy control group. Meta-analysis for A163G showed that allele G increased the risk of osteoporosis （ OR = 1.37, 95% CI： 1. 12 - 1.68, P =0. 003）. Stratified analysis showed that the magnitude of the effect was similar in Caucasian people, males and females, and postmenopausal women. Meta-analysis for T950C showed that allele T/C had no statistical significance on the risk of osteoporosis （OR = 1.03, 95% CI： 0. 82 - 1.28, P =0. 004）. Analysis in the subgroups also showed no statistical significance. Conclusion T950C polymorphisms are not associated with the risk of osteoporosis. However, A163G polymorphisms may increase the risk of osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2015年第9期1069-1075,共7页
Chinese Journal of Osteoporosis
基金
国家自然科学基金面上项目(81472989)
江苏省卫生厅社妇处(F201201)
