摘要
以N-(三苯基甲基)-5-(4'-溴甲基联苯-2-基)四氮唑为原料,经偶合、亲核取代、脱保护三步反应制得缬沙坦(1),总收率49.6%。该工艺路线短,操作简单,后处理容易,副产物较少。
Valsarain（1） was synthesized with N-（triphenylmethyl）-5- （4＇-bromomethylbiphenyl- 2-yl-） tetrazole as raw material via three steps： coupling, nucleophilic substitution and deprotection. The total yield was 49.6%. The preparation method has short process route, simple operation and fewer by-products.
出处
《当代化工》
CAS
2015年第9期2146-2147,共2页
Contemporary Chemical Industry
