摘要
呼吸道合胞病毒(Respiratory syncytial virus,RSV)是一种在世界范围内引起儿童急性下呼吸道感染的最为常见的重要病原。RSV介导的膜融合不需要吸附蛋白的参与,融合蛋白可单独完成膜融合过程,这与其它副粘病毒显著不同,其它主要副粘病毒介导的膜融合需要融合蛋白和吸附蛋白的共同参与。本综述就RSV膜融合相关研究的最新高水平论文加以综述,对目前流行的几种RSV膜融合理论解释模型加以比较分析,同时根据自己的研究心得对当前相关膜融合研究的热点和争议加以讨论,以期对我国在这方面的研究有所借鉴和参考。
The respiratory syncytial virus （RSV） is one of the most common causes of acute infection of the lower respiratory tract among children. For viruses in the Paramyxoviridae subfamily, membrane fusion requires a specific interaction between two glycoproteins： the fusion protein and attachment protein. Mem- brane fusion of the RSV appears to be unique among paramyxoviruses in that fusion is accomplished by the fusion protein alone without help from the attachment protein. Here, we review recent achievements and advances in the study of membrane fusion triggered by the RSV published in high-impact-factor journals. We also review and make a comparative analysis of the popular hypotheses regarding membrane fusion of the RSV. Finally, we discuss the ＂hot topics＂ in current research and controversial data published in re- cent years in the hope of providing references for Chinese researchers.
出处
《病毒学报》
CAS
CSCD
北大核心
2015年第5期565-572,共8页
Chinese Journal of Virology
基金
国家自然科学基金(31402218)
浙江省自然科学基金(LY14C180001)
教育部留学回国人员启动基金(511500040)
宁波大学人才引进工程项目(013-E00827134702)
关键词
副粘病毒
RSV
膜融合
机制
Paramyxovirus
Respiratory syncytial virus （RSV）
Membrane fusion
Mechanism
