摘要
目的:探讨16排CT灌注成像对非小细胞肺癌的鉴别诊断及其与微血管密度(MVD)、淋巴管密度(LVD)表达的相关性分析。材料与方法:选择69例均手术病理诊断证实的肺局限性病灶患者,根据诊断结果分为良性组(n=23)和恶性组(n=46),所有患者均行16排CT灌注成像,并将诊断结果与病理结果对比,对比两组CT灌注参数血容量(BV)和通透性(PMB)的差异;取10例手术切除的肺癌标本和对应的癌旁组织进行Elivision二步法免疫组织化学检测,计数MVD和LVD。pearson相关分析CT灌注参数与MVD和LVD计数的相关性。结果:16排CT灌注成像诊断肺恶性肿瘤的敏感度为91.30%,特异度为73.91%,准确度为85.51%;恶性组BV、PMB分别为(8.86±4.79)ml/100ml和(31.78±12.56)ml/100ml/min,均显著高于良性组,差异有统计学意义(P<0.05);肺癌组织MVD、LVD计数分别为13.48±5.57和10.44±4.21,均显著高于癌旁组织,差异有统计学意义(P<0.05);相关分析显示,BV与MVD呈显著正相关,PMB与MVD和LVD均呈显著正相关(P<0.05)。材料与方法:16排CT灌注成像对肺部良恶性病灶鉴别诊断具有重要作用,高灌注能一定程度反映非小细胞肺癌患者微循环管腔低成熟、高渗透以及肿瘤血管生成等生物学信息,对肿瘤的转移、侵袭力,乃至指导治疗和预后评估均具有重要的意义。
Purpose： To explore the differential diagnosis of 16 row CT perfusion imaging on Non-small cell lung cancer and the correlation with expression of microvascular density（ MVD）, lymphatic vessel density（LVD）. Materials and Methods ： Selected 69 cases Limitations lung lesions patients who proved by pathological diagnosis, they were divided into be- nign group （n = 23 ） and malignant group （ n = 46） according to the result of diagnosis, all the patients were performed CT perfusion imaging, and the diagnosis results were compared with the pathological results, compared two groups of CT perfu- sion parameters of blood volume （BV） and the difference of permeability （PMB） ; In 10 cases of surgically resected specimens of lung cancer and the corresponding tissue adjacent to carcinoma Elivision ldpe-g-nvp immunohistochemical detection, coun- ted MVD and LVD. Pearson correlation analysis of CT perfusion parameters and MVD and LVD count correlation. Results： The sensitivity, Specific degrees and accuracy of 16 row CT perfusion imaging in the diagnosis of pulmonary malignant tumor were respectively 91.30%, 73.91%, 85.51% ; The BV, PMB in malignant group were respectively （ 8.86 ± 4.79 ） ml/ 100mland（31.78±12. 56）ml/100ml/min, they were were significantly higher than in benign group, the difference was sta- tistically significant （P 〈0. 05） ; MVD, LVD count in lung tissue were respectively 13. 48 ±5. 57 and 10. 44 ±4. 21, they were were significantly higher than that of tissue adjacent to carcinoma, the difference was statistically significant （ P 〈 0. 05 ） ; Correlation analysis showed that BV and MVD was significantly positively related to PMB and MVD and LVD, it had signifi- cant positive correlation （P 〈0. 05）. Conclusion： 16 row CT perfusion imaging plays an important role in differential diagno- sis of benign versus malignant lung, high perfusion to a certain degree of microcirculation in patients with non-small cell lung cancer lumen low maturity, high permea
出处
《现代医用影像学》
2015年第3期303-306,共4页
Modern Medical Imageology
关键词
CT灌注成像
非小细胞肺癌
微血管密度
淋巴管密度
CT perfusion imaging
Non-small cell lung cancer
Microvascular density
Lymphatic vessel density
