摘要
目的 观察高尿酸血症患者血脂水平与冠状动脉慢性闭塞性病变（CTO）侧支循环的关系.方法 回顾性纳入于本院住院行冠状动脉造影（CAG）检查明确为CTO病变的高尿酸血症患者,分析血脂水平与高尿酸血症患者侧支循环（CC）形成情况的关系.结果 研究共纳入高尿酸血症患者30例,男性19例（63.7％）,平均年龄（64.5＆#177;11.5）岁.30例患者存在CTO病变血管32条,2例患者为双闭塞病变.其中CC良好组15例（男性11例,73.3％）,平均年龄（69.6＆#177;12.0）岁,CC不良组15例（男性8例,53.3％）,平均年龄（59.3＆#177;8.5）岁.CC不良组性别、合并高血压或者糖尿病、肝肾功能、空腹血糖、血尿酸水平、钾离子水平以及血小板数量、D-Dimer水平、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、左心室射血分数（LVEF）等与CC良好组比较均未见统计学差异.CC不良组年龄、总胆固醇（TC）、总甘油三酯（TG）与CC良好组比较差异有统计学意义（P＜0.05）.进一步的Logistic回归分析发现,上述因素均不是CC形成的独立危险因素.我们进一步分析了既往是否应用他汀药物治疗与CC形成及Rentrop血流情况的关系.结论 TC、TG和LDL-C水平及年龄对高尿酸血症患者CTO侧支循环的形成存在影响,HDL-C水平对侧支循环形成无显著影响,但是上述因素均不是影响CC形成的独立危险因素.是否应用他汀类药物治疗对侧支循环形成情况及Rentrop血流情况无明显影响.
Objective To investigate the relationship between the lipid profile and the collateral circula- tion （CC） in hyperuricemia patients with coronary chronic total occlusion （CTO） lesion. Methods Hyperuricemia patients with CTO lesion who received coronary angiography （CAG） test in our hospital were enrolled in the retro- spective analysis. The relationship between collateral circulation and the lipid profile were explored. Results 30 patients with 32 CTO lesions were enrolled in this analysis. 15 patients were enrolled in CC well development group （11 male patients, 73.3%）, the average age of CC well development group patients was （69.6~12.0）years, and 15 patents were enrolled in CC poor development group （8 male patients, 53.3% ） with the average age of （59.3~8.5）years. There was no significant difference of gender distribution, prior history of hypertension or dia- betes, liver and renal function, fast glucose, uric acid, potassium, platelet count, D-Dimmer, HDL-C, LDL-C and LVEF between CC poor-development group and CC well-development group. While there were significant dif- ference in gender, TC and TG between these two groups. Further Logistic regression analysis revealed that gender, TC and TG were not independent risk factor which can influence the formation of CC in hyperurecimia patients with CTO lesion. Further study revealed that prior statin therapy has no effect on the formation of CC and the Ren- trop score in these patients. Conclusion TC, TG, LDL-C and age are not independent risk factors which influ- ence the development of CC in hyperuricemia patients. Prior statin therapy has no significant influence on CC de- velopment and Rentrop flow grade.
出处
《中国心血管病研究》
CAS
2015年第9期814-817,共4页
Chinese Journal of Cardiovascular Research
关键词
血脂水平
冠状动脉慢性闭塞性病变
侧支循环
高尿酸血症
Lipid profile
Chronic coronary artery total occlusion
Collateral circulation
Hyperuricemia
