期刊文献+

创伤后应激障碍大鼠前额叶皮质PKMζ表达的变化 被引量:2

The alteration of PKMζ expression in the prefrontal cortex of PTSD rats
原文传递
导出
摘要 目的探讨创伤后应激障碍(PTSD)大鼠前额叶皮质PKMζ的表达变化情况。方法采用单程长时应激(SPS)制备PTSD大鼠模型,旷场试验、高架十字迷宫试验检测造模效果。将大鼠分为:SPS1d、SPS3d、SPS7d和SPS14d组,正常饲养大鼠作为对照组。利用Western blot和real-time RT-PCR检测PKMζ蛋白及m RNA在大鼠前额叶皮质表达。结果 SPS模型大鼠表现出明显的焦虑症状,SPS7d、SPS14d组大鼠前额叶皮质PKMζ蛋白和m RNA表达水平显著高于对照组。结论在应激后7d和第14d,PTSD大鼠前额叶皮质PKMζ表达显著增高。 Objective To investigate the aoteration of PKMζ expression in prefrontal cortex(PFC) of posttraumatic stress disorder(PTSD) rats. Methods The PTSD model was established by single prolonged stress paradigm(SPS), and identified by Open-field test and elevated plus-maze test. The PTSD rats were divided into: SPS1 d, SPS3 d, SPS7 d and SPS14 d groups, normal fed rats as a control group. The expression of PKMζ protein and mRNA in PFC was detected by Western Blot and real-time RT-PCR respectively. Results Behavioral test results showed that SPS rats had significant anxiety symptom. The expression levels of PKMζ protein and mRNA in prefrontal cortex of SPS7 d and SPS14 d rats were significantly higher compared to control group. Conclusion The overexpression of PKMζ in the PFC of PTSD rats indicates that PKMζ might be involved in the pathogenesis of PTSD.
出处 《解剖科学进展》 CAS 2015年第5期501-504,共4页 Progress of Anatomical Sciences
基金 辽宁省科技厅社会发展攻关计划(No.2012225021) 辽宁省自然科学基金项目(No.201102248)
关键词 创伤后应激障碍 前额叶皮质 PKMζ 大鼠 post-traumatic stress disorder prefrontal cortex PKMζ rat
  • 相关文献

参考文献14

  • 1Brunello N,Davidson JR,Deahl M,et al.Posttraumatic stress disorder:diagnosis and epidemiology,comorbidity and social consequences,biology and treatment[J].Neuropsychobiology,2001,43(3):150-162. 被引量:1
  • 2Vieweg WV,Julius DA,Fernandez A,et al.Posttraumatic stress disorder:clinical features,pathophysiology,and treatment[J].Am J Med,2006,119(5):383-390. 被引量:1
  • 3谢菊华,韩芳,石玉秀.PTSD大鼠海马RGMa的表达变化[J].解剖科学进展,2013,19(1):39-41. 被引量:4
  • 4Shin LM,Rauch SL,Pitman RK.Amygdala,medial prefrontal cortex,and hippocampal function in PTSD[J].Ann N Y Acad Sci,2006,1071:67-79. 被引量:1
  • 5Shema R,Haramati S,Ron S,et al.Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex[J].Science,2011,331(6021):1207-1210. 被引量:1
  • 6Song MJ,Jang JK,Kim WY,et al.Inhibition of PKMzeta in the nucleus accumbens core blocks the expression of locomotor sensitization induced by amphetamine[J].Behav Brain Res,2013,241:139-143. 被引量:1
  • 7Ji LL,Tong L,Xu BK,et al.Intra-hippocampal administration of ZIP alleviates depressive and anxiety-like responses in an animal model of posttraumatic stress disorder[J].Behav Brain Funct,2014,10:28.doi:10.1186/1744-9081-10-28. 被引量:1
  • 8George SA,Knox D,Curtis AL,et al.Altered locus coeruleusnorepinephrine function following single prolonged stress[J].Eur J Neurosci,2013,37(6):901-909. 被引量:1
  • 9Shajahan PM,Glabus MF,Steele JD,et al.Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity,but does not impair cognition in major depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2002,26(5):945-954. 被引量:1
  • 10Serrano P,Friedman EL,Kenney J,et al.PKMzeta maintains spatial,instrumental,and classically conditioned long-term memories[J].PLo S Biol,2008,6(12):2698-2706. 被引量:1

二级参考文献15

  • 1American Psychiatric Association. Diagnostic and statistical manual of mental disordersm[M].Washington DC:Ameri-can Psychiatric Association,1994. 被引量:1
  • 2Robinson BL,Shergill SS. Imaging in posttraumatic stress disorder[J].Current Opinion in Psychiatry,2011,(01):29-33. 被引量:1
  • 3Rauch SL,Shin LM,Phelps EA. Neurocirecuitry models of posttraumatic stress disorder and extinction:human neuroimaging research-past,present,and future[J].Biological Psychiatry,2006,(04):376-382. 被引量:1
  • 4Tischler L,Brand SR,Stavitsky K. The relationship between hippocampal volume and declarative memory in a population of combat veterans with and without PTSD[J].Annals of the New York Academy of Sciences,2006,(01):405-409. 被引量:1
  • 5Brinks H,Conrad S,Vogt J. The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the Dentate gyrus[J].Journal of Neuroscience,2004,(15):3862-3869. 被引量:1
  • 6Bonne O,Vythilingam M,Inagaki M. Reduced posterior hippocampal volume in posttraumatic stress disorder[J].Journal of Clinical Psychiatry,2008,(07):1087-1091. 被引量:1
  • 7Kitayama N,Vaccarino V,Kutner M. Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder:a meta-analysis[J].Journal of Affective Disorders,2005,(01):79-86. 被引量:1
  • 8Vythilingam M,Luckenbaugh DA,Lam T. Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder[J].Psychiatry Research,2005,(02):89-99. 被引量:1
  • 9Bae GU,Yang YJ,Jiang G. Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signalregulated kinase activities in vivo and in vitro[J].Molecular Biology of the Cell,2009,(23):4920-4931. 被引量:1
  • 10Katsuhiko H,Masashi F. RGMa inhibition promotes axonal growth and recovery after spinal cord injury[J].Cell Biology,2006,(01):47-58. 被引量:1

共引文献3

同被引文献10

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部