摘要
目的了解内蒙古自治区首例脊髓灰质炎(以下简称脊灰)疫苗病毒高变异株病例的流行病学相关情况.方法对病例开展个案调查、排毒监测及毒株鉴定,在其居住环境及周边医院开展主动搜索、接触者排毒监测和接种率调查,对可能存在的传播情况进行风险评估。结果在一例急性迟缓性麻痹病例(acute flaccid paralysis,AFP)的粪便标本中分离到脊灰Ⅱ型病毒,经国家脊灰实验室鉴定为脊灰Ⅱ型疫苗病毒高变异株。发病时间与病例免疫史相吻合,实验室监测显示该病例不再排毒。调查范围内脊灰疫苗第1和第2剂次接种率均为100%,第3和第4剂次均为99.67%;主动搜索未发现漏报病例;接触者中未监测到Ⅱ型病毒;经风险评估认为传播可能性低。结论这是内蒙古自治区首次发现由脊灰Ⅱ型疫苗病毒高变异株引起的病例,没有对周围人群造成传播和流行,疫情得到控制。
Objective To understand the epidemiological characteristics of a case caused by highly variant vaccine- derived poliovirus in Inner Mongolia province. Methods Case survey and virus excretion monitoring were carried out by investigators. Actively searching for cases from hospitals,immunization coverage rate survey and transmission risk assessment were performed at the same time. Results Polio virus typeⅡ was isolated from an acute flaccid paralysis（ AFP） case,the isolate was identified as highly variant vaccine- derived polio typeⅡ by nucleotide sequencing in state polio laboratory. Cases onset was identical with immune history,and laboratory tests showed that the cases are no longer detoxification. Survey found that the region has a higher immunization coverage rate,100% percent in 1^st and 2^n d times,and 99. 67% in the 3^rd and 4^th times; no omission of AFP cases. Integrated all the results of the survey,the incident is considered low risk. Conclusions The case caused by highly variant vaccine- derived poliovirus was the first time to be found in Inner Mongolia and no further transmission risk due to strict prevention and control measures.
出处
《医学动物防制》
2015年第8期888-890,共3页
Journal of Medical Pest Control
