摘要
目的 比较克罗米芬、来曲唑联合醋酸曲普瑞林（GnRH-a）诱导排卵在多囊卵巢综合征（PCOS）不孕患者促排卵中的应用效果。方法 60例PCOS不孕患者随机分为二组,克罗米芬组30例采用克罗米芬促排卵方案,来曲唑组30例采用来曲唑促排卵方案,当主导卵泡平均直径达18~22mm时,二组均采用GnRH-a0.1mg,皮下注射,以诱导排卵,比较二组月经第十天〉14mm卵泡个数、子宫内膜厚度、GnRH-a注射日子宫内膜的厚度、成熟卵泡个数、血清黄体生成素（LH）、雌激素（E2）水平、排卵率、妊娠率,卵巢过度刺激综合征（OHSS）发生率。结果 克罗米芬组患者第十天〉14mm卵泡数多、子宫内膜厚度薄,差异有统计学意义（P〈0.05）。GnRH-a日克罗米芬组成熟卵泡数多、子宫内膜厚度薄、血E2浓度高,差异有统计学意义（P〈0.05）。但血LH水平差异无统计学意义（P〉0.05）。二组比较排卵率、妊娠率差异均无统计学意义,克罗米芬组OHSS发生率高于来曲唑组,差异有统计学意义（P〈0.05）。结论来曲唑联合GnRH-a促排卵可以降低PCOS患者促排卵治疗中OHSS发生的危险。
Objective To explore the effect of Clomiphene（CC）, Letrozole Combined with GnRH- a on ovulation induction in the patients with polycystic ovary syndrome （PCOS）. Methods Totally 60 patients were divided into two groups, group CC （30 cases） was treated with CC and group Letrozole （30 cases） received Letrozole. When dominant follicle reach 18mm, injected GnRH - a 0. 1mg for trigger, and then the endometrial thickness,average dominant follicle numbers and levels of the E2, LH on GnRH - a day and the ovulation rates, the pregnancy rates,OHSS rates as well were evaluated. Results Group CC of patients had more average dominant follicle numbers and thinner endometrial thickness after five days treatment and GnRH - a day than that of group Letrozole （P〈0.05）, and also had the higher level of the E2 on GnRH- a day and the OHSS rates（P（0.05）. No significant difference was found in the level of LH, ovulation rate and clinical pregnancy rate（P〉0.05）. Conclusion Letrozole combined with GnRH - a can be widely used in intrauterine insemination in patients with PCOS.
出处
《中国煤炭工业医学杂志》
2015年第10期1645-1647,共3页
Chinese Journal of Coal Industry Medicine
基金
2010年唐山市科学技术研究与发展指导计划项目(编号:09130246b)
关键词
克罗米芬
来曲唑
促性腺激素释放激素激动剂
多囊卵巢综合征
宫腔内人工授精
Clomiphene
Letrozole
Gonadotropin releaseing hormone agonist（GnRH - a）
Polycystic ovary syndrome（PCOS）
Intra uterine insemination（IUI）
