摘要
目的:探索SPB基因1580位点多态性与我国新生儿呼吸窘迫综合征易感性的关系。方法:计算机检中国知网、维普、万方、Pub Med等中英文数据库,检索年限:2000年1月1日至2015年6月10日,限定中文文检索词,确定文献的纳入和排出标准,进行资料提取和质量评价,应用Rev Man5.0软件进行分析。结果:共纳入5项研究,包括新生儿呼吸窘迫综合征病例631例,对照组581例。Meta分析结果显示,病例组具有突变型(CT/CC)基因表达的比例及C等位基因的频率均高于对照组,其OR值及95%CI分别为2.01(1.40,32.89)和1.84(1.24,2.76)(P<0.05)。结论:SPB基因1580位点多态性与我国新生儿呼吸窘迫综合征易感性存在关联。但由于纳入研究的数量少、研究类型局限,尚不能得出肯定性的结论。有必要继续开展高质量、大样本的人群研究。
Objective： To explore the relationship between surfactant protein B （SPB） gene 1580 polymorphism and neonatal re- spiratory distress syndrome in Chinese neonates. Methods： Literatures on the relationship between the SPB gene 1580 polymorphism and neonatal respiratory distress syndrome in Chinese neonates in CNKI, VIP, Wanfang, MEDLINE, PubMed were searched from Jan 1, 2000 to Jun 10, 2015 according to the inclusion and exclusion criteria. Chinese and English indexing vocabulary was limited. The quality was evaluated and Meta-analysis was performed by RevMan5.0 software. Results： A total of 5 studies were included. There were 631 cases of neonatal respiratory distress syndrome, and 581 of control in total. Meta-analysis showed that the proportion of mutant （CT/CC） gene expression and the frequency of C gene in the case group was higher than that in control group, OR values and 95% confidence interval were 2. 01 （ 1.40, 32. 89）, 1.84 （ 1.24, 2. 76）, respectively. Conclusions： SPB gene 1580 poly- morphism was associated with the neonatal respiratory distress syndrome susceptibility in Chinese neonates. Due to few studies, poten- tial bias, and low quality of studies, reliable conclusions cannot be drawn from the present data. High quality studies should be per- formed further.
出处
《沈阳医学院学报》
2015年第3期179-182,共4页
Journal of Shenyang Medical College
基金
沈阳医学院大学生科研基金项目(No.20139031)
沈阳医学院科研基金项目(No.20122036)
