摘要
目的:探讨影响病毒性脑炎(VE)患者发生癫痫的相关因素。方法:收集成人VE患者159例临床资料并进行随访,分析一般情况、发热、意识障碍程度、癫痫发作频率、神经系统阳性体征、脑脊液、病原学和脑电图等辅助检查结果,探讨VE恢复期癫痫发生的相关因素。结果:随访中34例(21.4%)出现继发性癫痫,纳入病例组,其中19例(55.9%)最终发展为难治性癫痫;未发生PEE患者125例(78.6%),纳入对照组。2组急性期意识障碍、癫痫反复发作和持续状态、大脑皮质损害、局灶性脑电图异常和脑脊液单纯疱疹病毒阳性差异具有统计学意义(P<0.05)。结论:VE急性期意识障碍、癫痫反复发作、癫痫持续状态、大脑皮质损害、局灶性脑电图异常和脑脊液单纯疱疹病毒阳性可能是恢复期继发性癫痫的相关因素。
Objective： To investigate the related factors for the occurrence of postencephalitic epilepsy （PEE） in patients with viral encephalitis （VE）. Methods： One hundred and fifty-nine cases with VE in adults were followed up. The clinical data including general condition, fever, consciousness level, seizure frequency, focal neurological sign, cerebrospinal fluid parameter, central nervous system infection and electroencephalography findings were analyzed. Results： Of the total 159 patients, 34 （21.4%） were found to develope epilepsy （case group）, in which 19 （55.9%） harbored refractory epilepsy. There was significant difference in consciousness level, seizure frequency, focal cortical abnormalities, focal cerebral dysfunction and herpes simplex virus infection during the acute phase between the epileptic cases and the cases without epilepsy （P〈0.05）. Conclusion： The presence of coma, recurrent seizures or status epilepticus, focal cortical abnormalities in neuroimaging, focal cerebral dysfunction in electroencephalography and herpes simplex virus infection during the acute phase of VE are potential risk factors of PEE.
出处
《神经损伤与功能重建》
2015年第5期406-408,共3页
Neural Injury and Functional Reconstruction
