摘要
弥散性血管内凝血（ DIC）是一个非常复杂的病理生理过程，促凝和抗凝因子及血小板均有消耗，根据临床表现和实验室检查很难准确判断疾病的真实临床进程，处理上常常需要结合所在医院习惯和专家的经验。不同类型DIC的处理、用药的剂量与方案存在诸多的不确定性。有关DIC的治疗，儿科目前主要参考成人的指南。DIC最重要的处理措施是对潜在疾患进行强有力的治疗，消除触发凝血病变危险因素，同时采用恰当的血液制品进行复苏。尚无临床随机试验证实应用肝素在DIC患者能改善临床相关结果，活化蛋白C、抗凝血酶、组织因子通路抑制物和血栓调节素等抗凝因子在DIC治疗中的意义还有待于更多高质量的临床研究深入探讨。
Disseminated intravascular coagulation （ DIC ） is a exceedingly complicated pathophysiological process,both pro and anti coagulation factors are activated and consumed,it is difficult to determine acute stage of the syndrome for physicians based on clinical presentations and laboratory tests,management strategy of DIC is not same due to different etiology,the dose and regimen of drug administration are uncertain. At present pediatricians usually treat children patients with DIC according to researches and guidelines for adults. The key strategies to DIC management is to treat underlying diseases aggressively so as to clear risk factors triggering extensive coagulation and resuscitate with ap-propriate blood products. No clinical trials have proved that heparin can improve clinical outcome,efficacies of activated protein C,antithrombin, tissue factor pathway inhibitor and thrombomodulin are needed to be verified by more high qua-lity clinical trials in DIC treatment.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2015年第18期1368-1371,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
弥散性血管内凝血
治疗
儿童
Disseminated intravascular coagulation
Therapy
Child
