摘要
蛋白质乙酰化修饰对基本生命现象进行广泛调节,如心血管稳态和肿瘤发生。探索乙酰化修饰机制及其在疾病中的异常表现,已成为医学研究的基本问题之一。血管衰老与老年性高血压、冠状动脉粥样硬化等疾病的发生发展密不可分,内皮细胞衰老是其中的关键环节。该文综述了血管衰老的乙酰化调节研究进展,并对该领域的研究做展望。
Protein acetylation extensively regulates fundamental biological process, such as cardiovascular homeostasis and tu-morigenesis. Mechanism of protein acetylation and its abnormal changes during diseases has become one of the basic questions in medical research. Vascular aging is inseparable from the occur-rence and development of senile hypertension and coronary ather-osclerosis. Endothelial cell senescence plays a key role during this process. This paper reviews the research progress in acetyla-tion regulation during vascular aging, and the prospects of the re-search in this field.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2015年第10期1348-1351,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金青年项目(No 81000045)
复旦大学老年医学研究中心项目(No 13dz2260700)
上海市浦江人才计划资助项目(No 15PJ1406100,15PJ1400700)
关键词
乙酰化
衰老
内皮细胞
硫化氢
血管新生
组蛋白去乙酰化酶
acetylation
senescence
endothelial cells
hydrogen sulfide
angiogenesis
histone deacetylase
