摘要
类风湿关节炎（rheumatoidarthritis，RA）是一种慢性、炎性、自身免疫性疾病，主要累及关节和滑膜，其发病机制尚待探明，遗传因素在RA的发病中起着重要作用。RA的易感基因除人类白细胞抗原（humanleukocyteantigen，HLA）区域的HLA—DRB等基因外，还有非HLA区域的TIM3、PTPN22、TRAF1／C5、STAT4、CCR5、PAD14、FCGR2A等基因。
Rheumatoid arthritis （RA） is a chronic, inflammatory, autoimmune disorder that principally attacks flexible joints and synovia. The precise pathogenesis of RA remains unclear, and genetic factors probably play an important role in its etiology. In addition to genes from human leukocyte antigen （HLA） region, such as HLA-DRB, genes from non-HLA region, such as TIM-a. PTPN22, TRAF1/CS, STAT4, CCRS, PADI4 and FCGR2A may also contribute to its susceptibility. The advance in molecular genetics research on RA is reviewed here.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2015年第5期728-733,共6页
Chinese Journal of Medical Genetics
关键词
类风湿关节炎
分子遗传学
易感基因
Rheumatoid arthritis
Molecular genetics
Susceptible gene
