摘要
目的:探讨乙肝肝硬化并发原发性肝癌的相关危险因素,寻找重要的独立危险因素为预防原发性肝癌提供参考。方法:回顾性分析170例乙肝肝硬化患者的临床资料,将85例乙肝肝硬化并发原发性肝癌患者作为观察组,以同期住院的85例乙肝肝硬化患者作为对照组,对可能导致原发性肝癌的主要相关危险因素进行分析,对有显著性差异的因素进行单因素Logistic回归分析,再对两组中有统计学意义的因素应用多因素非条件Logistic回归分析。结果:单因素Logistic回归分析显示长期饮酒史、代谢综合征、未抗病毒治疗、HBV DNA阳性、HBsAg阳性、抗-HBe阳性进入多因素回归方程,多因素非条件Logistic回归分析显示代谢综合征、未抗病毒治疗、HBV DNA阳性、HBsAg阳性、抗-HBe阳性(OR值分别为4.512,1.626,2.106,1.149,4.625)均是乙肝肝硬化并发原发性肝癌的独立危险因素。结论:乙肝肝硬化患者如同时伴随HBV DNA阳性、HBsAg阳性、抗-HBe阳性,并有代谢综合征及未抗病毒治疗均是原发性肝癌的高危人群。
Objective ：To explore the related risk factors of hepatocellular carcinoma due to hepatitis B cirrhosis ,to look for an important independent risk factors as to provide reference for predicting hepatocellular carcinoma .Methods ：A retrospective analysis of the clinical data of 170 cases patients with hepatitis B cirrhosis ,85 cases of hepatocellular carcinoma due to hepatitis B cirrhosis as the observation group ,85 cases of hepatitis B cirrhosis as the control group , major related risk factors that may lead to hepatocellular carcinoma were analyzed ,there were statistic significance by single factor Logistic regression analysis ,and then there were statistic significance between the two groups by multiva‐riate and unconditioned Logistic regression analysis .Results：Single factor Logistic regression analysis showed that long‐term drinking history ,metabolic syndrome ,not antiviral treatment ,HBV DNA‐positive ,HBsAg‐positive ,anti‐HBe‐pos‐itive ,entered the multi‐factor regression equation ,multivariate and unconditioned Logistic regression analysis showed that the metabolic syndrome ,not antiviral treatment ,HBV DNA‐positive ,HBsAg‐positive ,anti‐HBe‐positive（OR val‐ues were 4 .512 ,1 .626 ,2 .106 ,1 .149 ,4 .625 ,respectively）were independent risk factors hepatocellular carcinoma due to B cirrhosis .Conclusion：Patients with hepatitis B cirrhosis ,such as with HBV DNA‐positive ,HBsAg‐positive ,anti‐HBe‐positive ,and the metabolic syndrome and not antiviral treatment at the same time were high‐risk groups of hepatocellu‐lar carcinoma .
出处
《医学理论与实践》
2015年第18期2433-2435,共3页
The Journal of Medical Theory and Practice
