摘要
MicroRNA是一组内源性高度保守的单链非编码RNA小分子,约由22个核苷酸组成,通过抑制靶基因信使RNA(mRNA)翻译或促进mRNA降解等方式调控基因的表达。近年研究发现,microRNA参与人体多种病理生理过程,其中,microRNA的异常表达与急性心肌梗死的发生、进展密切相关,急性心肌梗死患者血浆中microRNA显著升高,同时参与随后一系列病理过程,并具有高度心脏特异性,本文就microRNA与心肌梗死的心脏病理特征作一综述。
MicroRNA is a type of small molecular non-coding RNA with the length about 22 nucleotides who regulates the expression of gene at the posttranscriptional level.Studies have shown that microRNA play important roles in a variety of physiological and pathological processes such as proliferation and differentiation.Recent years,study show that aberrant expression of microRNA can contribute to various disease,such as myocardial infarction.Moreover,the expression levels of some microRNA is specifically involved in the molecular pathogenesis of MI,revealing their great potential as a class of novel biomarkers for MI and therapeutic targets.In this review,we summarizes the relationship between microRNA and myocardial pathological following MI.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第9期928-931,共4页
Journal of Clinical Cardiology
基金
江苏省临床科技专项(No:BL2012042)
关键词
微小RNA
心肌梗死
心脏病理
microRNA
myocardial infarction
cardiac pathology
