摘要
目的探讨急性脑梗死（ACI）患者血清CXC趋化因子配体16（CXCL16）水平与颈动脉粥样硬化的相关性。方法选取36例ACI患者为ACI组,同期体检者30例为对照组,检测血脂、超敏C反应蛋白（hs-CRP）和血清CXCL16水平,并应用彩色多普勒超声检查颈动脉粥样硬化斑块及颈动脉内膜-中膜厚度（IMT）变化情况。结果ACI组血清CXCL16水平[3.58（1.06～12.83）ng/L]高于对照组[1.57（0.61～3.34）ng/L],差异有统计学意义（P〈0.05）;ACI组颈动脉IMT[（1.19±0.36）mm]高于对照组[（1.01±0.18）mm],差异有统计学意义（P〈0.05）;ACI组中,不稳定性斑块患者CXCL16水平高于稳定性斑块患者,差异有统计学意义（P〈0.05）,血清CXCL16水平与颈动脉IMT和hs-CRP水平均呈正相关（r=0.497,P〈0.05;r=0.442,P〈0.05）;多元线性逐步回归分析显示,CXCL16是动脉粥样硬化斑块形成的重要危险因子之一。结论高血清CXCL16和hs-CRP水平为颈动脉粥样硬化斑块形成的独立危险因素,CXCL16与颈动脉粥样硬化斑块的易损性密切相关。
Objective To explore the correlation between serum levels of CXC chemokine ligand 16（CXCL16） and carotid artery atherosclerosis in patients with acute cerebral infarction（ACI） .Methods A total of 36 cases of patients with ACI were enrolled in ACI group ,and 30 individuals received physical examination were enrolled into control group .Levels of blood lipid ,high‐sensitive C‐reactive protein（hs‐CRP） and serum CXCL16 were detected ,and the carotid atherosclerotic plaques and changes of carotid intimal‐medial thickness（IMT） were examined by using the Color Doppler ultrasonography .Results The serum levels of CXCL16 in ACI group[3 .58（1 .06 -12 .83）ng/L] was higher than that in control group[1 .57（0 .61 -3 .34）ng/L] ,had statistically significant difference（P〈0 .05） .The carotid IMT were higher in ACI group[（1 .19 ± 0 .36）mm] than that in control group[（1 .01 ± 0 .18） mm] ,had statistically significant difference（P〈0 .05） .In ACI group ,the serum level of CXCL16 was higher in patients with vul‐nerable plaques than that in patients with stable plaques ,had statistically significant difference（P〈0 .05） ,Serum levels of CXCL16 were correlated with carotid IMT and levels of hs‐CRP（r=0 .497 ,P〈0 .05 ;r=0 .442 ,P〈0 .05） .Multiple linear stepwise regres‐sion analysis showed that CXCLl6 was one of the independent risk factors for the development of carotid atherosclerotic plaques . Conclusion High serum levels of CXCLl6 and hs‐CRP might be independent risk factors for the development of carotid atheroscle‐rotic plaques ,and CXCLl6 might be closely correlated to the vulnerability of carotid atherosclerosis plaques .
出处
《国际检验医学杂志》
CAS
2015年第18期2686-2687,2690,共3页
International Journal of Laboratory Medicine
