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表观弥散系数在腰椎间盘退变中的研究进展 被引量:1

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摘要 腰椎间盘退变是腰腿痛的主要原因之一,客观、无创、早期定量评估腰椎间盘退变,对病变的预防、临床诊疗及疗效评估具有重要意义.MRI是目前诊断椎间盘退变最为简单、准确而无损伤的检查方法,常规磁共振T2WI强调退变椎间盘形态和信号的改变,缺乏椎间盘退变量化的评价标准.椎间盘水分子弥散受损是椎间盘退变标志性改变[1],而弥散加权成像(diffusion weighted imaging,DWI)是目前唯一能检测活体组织内水分子弥散运动的无创性方法.通过测量表观弥散系数值(apparent diffusion coefficient,ADC)可以定量评估椎间盘自由水的弥散运动,间接反映椎间盘蛋白多糖、胶原分子等微观信息[2,3],因此,ADC值对腰椎间盘退变的研究具有重要意义.现就DWI-ADC值在腰椎间盘退变中的最新研究进展综述如下.
出处 《浙江临床医学》 2015年第10期1808-1810,共3页 Zhejiang Clinical Medical Journal
基金 南京军区科研基金(10MA128) 浙江省医学会临床科研基金(2011ZYC-A43)
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