摘要
目的提高对CD4＋／CD8-T-大颗粒淋巴细胞白血病的认识。方法分析1例因皮疹、白细胞增多就诊的CD4＋／CD8-T-大颗粒淋巴细胞白血病患者的临床资料，并复习相关文献。结果患者为老年女性，周身散在片状紫红色斑疹，外周血大颗粒淋巴细胞增多，呈CD3＋／CD4＋／CD8-免疫表型，PCR检测TCRγ、β基因重排阳性，流式细胞术检测TCRVβ亚家族98％。结论CD3VCD4＋／CD8-变异型T-大颗粒淋巴细胞白血病少见，临床表现与经典T-大颗粒淋巴细胞白血病有所不同，应谨慎鉴别。
Objective Presenting the clinical features of one patient with CD4＋/CD8- T-cell large granular lymphocytic leukemia, to improve the understanding of the disease. Methods Clinical data of one patient hospitalized for skin rush and leukocytosis were analyzed, and the related literatures were reviewed. Results The patient was hospitalized for skin rush and leukocytosis. Routine blood test showed remarkable elevated white blood cell counts and mild anemia. Subsequent hematological examination led to a diagnosis of T-cell large granular lymphocytic leukemia with CD4 ＋/CD8- immunophenontype. Conclusion CD3 ＋/CD4＋/CD8- T-cell large granular lymphocytic leukemia is a kind of variant subtype, and is relatively rare, it has different clinical features with classic CD3 ＋/CD4-/CD8 ＋/TCRαβ＋T- cell large granular lymphocytic leukemia, so differentiating diagnosis is of great importance.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2015年第9期739-742,共4页
Chinese Journal of Hematology
关键词
白血病
大颗粒淋巴细胞
诊断
鉴别
Leukemia, large granular lymphocytic
Diagnosis, differential
