摘要
肝移植受者是罹患代谢病的高危人群。肝移植术后代谢病的发生与免疫抑制刑、心血管疾病、肾病、感染等关系密切，在很大程度上影响受者的长期生存。本共识旨在为中国肝移植受者术后代谢病的防治提供建议，以期改善受者的长期生存。代谢病以肥胖症、糖尿病、高血压病、高脂血症为典型特征。代谢病的防治应以改变饮食习惯和生活方式为基础，调整免疫抑制方案，并适当使用药物治疗。建议在保证移植肝功能的前提下将可能导致代谢病的免疫抑制剂减量。含霉酚酸酯的无激素及钙调神经磷酸酶抑制刑最小化方案对减少肝移植术后代谢病的发生有益。
Liver transplant recipients are at high risk of metabolic diseases, which are closely associated with immuno- suppressive regimens, cardiovascular diseases, renal dysfunction and infection, having significant influence on long-term survival of recipients. This consensus is to give advices on the prophy- laxis and treatment of metabolic diseases in the Chinese liver transplant recipients. Metabolic diseases are characterized by o- besity, hyperglycemia, hypertension and hyperlipidemia. Man- agement of metabolic diseases should be combined with lifestyle modification, adjustment of immunosuppressive regimen and medical therapy. It is advised to reduce certain immunosuppres- sant that may contribute to metabolic disease on the premise of normal graft function, and the combined regimen of mycopheno- late mofetil and minimized steroid and calcineurin inhibitors is considered to be beneficial.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2015年第9期577-581,共5页
Chinese Journal of Hepatobiliary Surgery
基金
国家科技部传染病重大专项十二五流动立项（2012ZX10002-017）
国家高技术研究发展计划（863计划）（2012AA020204）
国家自然科学基金创新群体（81421062）
关键词
肝移植
代谢病
糖尿病
高血压病
高脂血症
免疫抑制剂
共识
Liver transplantation
Metabolic disea-ses
Diabetes mellitus
Hypertension
Hyperlipidemia
Immunosuppressant
Consensus
