摘要
目的探讨纤维支气管镜肺灌洗术治疗重度颅脑损伤患者肺部感染的临床疗效,为临床降低肺部感染的发生率提供参考。方法选取2011年9月-2014年11月医院接诊的66例重度颅脑损伤发生肺部感染患者,按照入院时间先后顺序将其分为两组,各33例,对照组给予常规治疗,观察组在常规治疗的基础上给予纤维支气管镜肺灌洗术治疗,比较两组患者的治疗情况、各项治疗指标、疗效以及不良反应。结果观察组机械通气时间、发热时间、肺部啰音消失时间、抗菌药物使用时间均短于对照组,观察组感染控制时间、二氧化碳分压优于对照组;观察组细菌培养阳性率、血氧饱和度均高于对照组;观察组的病死率为0.09%、总有效率为90.90%,对照组分别为30.30%、54.45%,两组比较差异均有统计学意义(P<0.05);两组不良反应比较差异无统计学意义。结论纤维支气管镜肺灌洗术治疗重度颅脑损伤合并肺部感染的临床疗效良好、安全性较高,值得临床推广应用。
OBJECTIVE To evaluate the clinical efficacy of fiberoptic bronchoalveolar lavage in the treatment of pulmonary infected patients with severe head injury so as to provide reference for the reduction of pulmonary infection rate.METHODS Totally 66 patients with severe head injury and pulmonary infection from Sep.2011 to Nov.2014 in our hospital were researched.According to admission chronological order,they were randomly divided into two groups with 33 cases each.The control group was treated with conventional method.The observation group received bronchoscopy lung lavage in addition to the conventional therapy.Two groups′treatment condition,the therapeutic indexes,efficacy,and adverse reactions were compared.RESULTS The mechanical ventilation,duration of fever,pulmonary rales disappeared time,antibiotics using time of the observation group were significently shorter than those of the control group（P〈0.05）;the infection control time,carbon dioxide partial pressure of the observation group were significently better than the control group（P〈0.05）;the bacterial positive rate,oxygen saturation of observation group were significently higher than those of the control group（P〈0.05）.Mortality in the observation group was 9.09%,in the control group was 30.30%and the total effective of observation group（90.90%）was significantly higher than the control group（54.45%）（P〈0.05）;there was no significant difference of patients in the control group and the observation group in the adverse reactions（P〉0.05）.CONCLUSION Fiberoptic bronchoalveolar lavage has good clinical efficacy,high safety in treating pulmonary infected patients with severe head injury,hence is worth to be promoted in clinical practices.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第18期4233-4235,共3页
Chinese Journal of Nosocomiology
基金
山东省科技厅基金资助项目(Z-2014-1-3-46-1)
关键词
纤维支气管镜肺灌洗术
重度颅脑损伤
肺部感染
Fiberoptic bronehoalveolar lavage
Severe brain injury
Pulmonary infection
