摘要
目的:本实验旨在研究针刺足三里、阳陵泉治疗急腹症术后胃肠功能紊乱的机制.方法:将40只SD大鼠分为5组,正常组作为对照组不进行处理,其他4组选择丝线单纯结扎法制作不完全肠梗阻大鼠模型造模处理.模型1 d组和模型2 d组不进行处理,针刺1 d组和针刺2 d组选取足三里、阳陵泉给予针刺治疗,处死大鼠,运用酚红试剂检测小肠推进率水平,应用ELISA方法检测并对比模型大鼠血清中肿瘤坏死因子-?(tumor necrosis factor-?,TNF-?)、白介素-6(interleukin-6,IL-6)含量.结果:TNF-?和IL-6含量:针刺1 d组和模型1 d组、针刺2 d组和模型2 d组比较均有显著差异(P<0.05),针刺1 d组和针刺2 d组比较无显著统计学差异(P>0.05);酚红试剂小肠推进率百分比:针刺1 d组和模型1 d组、针刺2 d组和模型2 d组比较均有显著性差异(P<0.05),针刺2 d组和针刺1 d组比较亦有显著统计学差异(P<0.05).结论:针刺足三里、阳陵泉可以降低不完全肠梗阻模型大鼠血清中的TNF-?和IL-6浓度含量.针刺足三里、阳陵泉可以提高不完全肠梗阻模型大鼠小肠的推进率,加快肠道运动.
AIM： To reveal the mechanism by which acupuncture treatment promotes gastrointestinal function recovery in acute abdomen disease. METHODS： Forty SD rats were randomlydivided into five groups. Rats in the normal group were not given any surgery or treatment, and rats in other four groups（1- and 2-day model groups and 1- and 2-day treatment groups） were given an operation to obstruct the ileum by thread ligation. The two treatment groups were given acupuncture at Zusanli and Yanglingquan acupoints. Serum levels of tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） were compared between different groups, and the rate of small intestinal transit was also compared. RESULTS： Serum concentrations of TNF-α and IL-6 differed significantly between the 1-day acupuncture group and 1-day model group, as well as between the 2-day acupuncture group and 2-day model group, although there was no significant difference between the 1- and 2-day acupuncture groups. The rate of small intestinal transit differed signifi cantly between the 1-day acupuncture group and 1-day model group, between the 2-day acupuncture group and 2-day model group, as well as between the 1- and 2-day acupuncture groups. CONCLUSION： Acupuncture at Zusanli and Yanglingquan acupoints can increase serum levels of TNF-α and IL-6 and the rate of small intestinal transit in rats with incomplete intestinal obstruction.
出处
《世界华人消化杂志》
CAS
2015年第24期3894-3898,共5页
World Chinese Journal of Digestology
关键词
不全性肠梗阻
肿瘤坏死因子-α
白介素-6
针刺
Incomplete intestinal obstruction
Tumor necrosis factor-α
Interleukin-6
Acupuncture
